Role of Tumor Necrosis Factor Alpha Promoter Polymorphisms in Interferon Related Side Effects in Chronic Hepatitis B Patients Under Interferon Alpha 2b Treatment

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dc.contributor.authorİnkaya, Ahmet Çağkan
dc.contributor.authorArıbaş, Emel Türk
dc.contributor.authorKandemir, Bahar
dc.contributor.authorAcar, Hasan
dc.contributor.authorBitirgen, Mehmet
dc.date.accessioned2020-03-26T20:11:53Z
dc.date.available2020-03-26T20:11:53Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Interferon alpha therapy is associated with series of adverse ef-fects leading premature discontinuation of treatment. Here we aimed to de-termine the effects of Tumor necrosis alpha promoter polymorphisms on in-terferon related side effects during interferon alpha 2b treatment in chron-ic hepatitis B patients.Material and Methods: This observational study enrolled 50 chronic hepati-tis B patients, who were treated with interferon alpha 2b 10 tiw plus lamivu-dine 100mg/day at Selçuk University Meram Medical Faculty Department of Infectious Diseases and Clinical Bacteriology between 2006-2007. Patients were followed-up with complete blood count, transaminases and amylase monthly at out patient clinics of our department. All patients were asked to fill a questionnaire to evaluate the interferon related side effects at every vis-it. Tumor necrosis factor alpha -238 and -308 polymorphisms were investi-gated with PCR-Restriction fragment length polymorphisms.Results: Arthralgia was present in 93.8% of patients. Exhaustion, loss of ap-petite, mount dryness and fever are the leading complaints of the patients. Median complaint scores were 9, 9.5, 11 and 5 at 4th, 12th, 24th and 48th week visits, respectively. Thrombocytopenia and leucopenia were detected in 8 (16%) and 5 (10%) patients, respectively. One-third of the patients report-ed depressive mood however, depression was diagnosed in 5 (10%) patients. TNF alpha promoter 238GG and 308GG allele was present in 42/50 and 43/50 patients, respectively. No association was found between TNF pro-moter allele and certain patient-reported side effect, complaint score, hema-tological and psychological adverse effects. Conclusion: TNF alpha promoter polymorphisms do not contribute to oc-currence of IFN alpha treatment related side effects.en_US
dc.identifier.citationİnkaya A. Ç., Arıbaş E. T., Kandemir B., Acar H., Bitirgen M. (2019). Role of Tumor Necrosis Factor Alpha Promoter Polymorphisms in Interferon Related Side Effects in Chronic Hepatitis B Patients Under Interferon Alpha 2b Treatment. Acta Medica, 50(2), 32-38.
dc.identifier.endpage38en_US
dc.identifier.issn2147-9488en_US
dc.identifier.issue2en_US
dc.identifier.startpage32en_US
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TXpFME1qWTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37262
dc.identifier.volume50en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofActa Medicaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcil Tıpen_US
dc.subjectAdli Tıpen_US
dc.subjectAlerjien_US
dc.subjectAnatomi ve Morfolojien_US
dc.subjectAndrolojien_US
dc.subjectAnestezien_US
dc.subjectBiyofiziken_US
dc.subjectBiyokimya ve Moleküler Biyolojien_US
dc.subjectBiyolojien_US
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyolojien_US
dc.subjectCerrahien_US
dc.subjectDermatolojien_US
dc.subjectEndokrinoloji ve Metabolizmaen_US
dc.subjectEnfeksiyon Hastalıklarıen_US
dc.subjectFizyolojien_US
dc.subjectGastroenteroloji ve Hepatolojien_US
dc.subjectGenel ve Dahili Tıpen_US
dc.subjectGeriatri ve Gerontolojien_US
dc.subjectGöz Hastalıklarıen_US
dc.subjectHalk ve Çevre Sağlığıen_US
dc.subjectHematolojien_US
dc.subjectHücre Biyolojisien_US
dc.subjectİmmünolojien_US
dc.subjectKadın Hastalıkları ve Doğumen_US
dc.subjectKalp ve Kalp Damar Sistemien_US
dc.subjectKlinik Nörolojien_US
dc.subjectKulaken_US
dc.subjectBurunen_US
dc.subjectBoğazen_US
dc.subjectMikrobiyolojien_US
dc.subjectNörolojik Bilimleren_US
dc.subjectOdyoloji ve Konuşma-Dil Patolojisien_US
dc.subjectOnkolojien_US
dc.subjectOrtopedien_US
dc.subjectPatolojien_US
dc.subjectPediatrien_US
dc.subjectPeriferik Damar Hastalıklarıen_US
dc.subjectPsikiyatrien_US
dc.subjectRadyolojien_US
dc.subjectNükleer Tıpen_US
dc.subjectTıbbi Görüntülemeen_US
dc.subjectRehabilitasyonen_US
dc.subjectRomatolojien_US
dc.subjectSağlık Bilimleri ve Hizmetlerien_US
dc.subjectSolunum Sistemien_US
dc.subjectSpor Bilimlerien_US
dc.subjectTamamlayıcı ve Entegre Tıpen_US
dc.subjectTemel Sağlık Hizmetlerien_US
dc.subjectTıbbi Araştırmalar Deneyselen_US
dc.subjectTıbbi Etiken_US
dc.subjectTıbbi İnformatiken_US
dc.subjectTıbbi Laboratuar Teknolojisien_US
dc.subjectTransplantasyonen_US
dc.subjectTropik Tıpen_US
dc.subjectÜroloji ve Nefrolojien_US
dc.subjectYoğun Bakımen_US
dc.subjectTıpen_US
dc.titleRole of Tumor Necrosis Factor Alpha Promoter Polymorphisms in Interferon Related Side Effects in Chronic Hepatitis B Patients Under Interferon Alpha 2b Treatmenten_US
dc.typeArticleen_US

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