Novel Perspectives on Two Digitalis Species: Phenolic Profile, Bioactivity, Enzyme Inhibition, and Toxicological Evaluation

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dc.authorid0000-0002-7795-8482
dc.authorid0000-0002-8901-6484
dc.authorid0000-0002-8537-3978
dc.contributor.authorKatanić, Jelena
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorMatić, Sanja
dc.contributor.authorBoroja, Tatjana
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMihailović, Vladimir
dc.contributor.authorStanić, Snežana
dc.date.accessioned2020-03-26T19:42:10Z
dc.date.available2020-03-26T19:42:10Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe present study outlines the phenolic composition of methanolic extracts of Digitalis ferruginea and Digitalis lamarckii aerial parts and evaluates their biological activities. The quantification of phenolic compounds was carried out by HPLC-DAD analysis. Antioxidant properties were assessed using different assays. Enzyme inhibition was tested on AChE, BChE, alpha-amylase, alpha-glucosidase, and tyrosinase. The antimicrobial properties of the extracts were determined using the microdilution method. Genotoxicity of the extracts was assessed on Drosophila melanogaster by comet assay. D. lamarcki extract was richer in phenolic compounds than D. ferruginea, with chlorogenic acid as dominant compound in both D. lamarckii and D. ferruginea extracts (2.99 and 1.30 mg/g, respectively). Both extracts showed similar values in terms of antioxidant activity. The extracts showed enzyme inhibitory activity on above-mentioned enzymes and moderate antimicrobial activity (MIC range 0.625-10 mg/mL). D. ferruginea extract (20 mg/mL) indicated the absence of genotoxicity, while all concentrations of D. lamarckii extract showed significant DNA damage. Antigenotoxic effect was more evident in the group treated with D. lamarckii extract, 80 mg/mL (% R = 80.3). The results emphasized the biological potential of examined plants and encourage further studies for their potential use as phytopharmaceuticals. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia [III 43004, 41010]en_US
dc.description.sponsorshipThis research was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (projects No. III 43004 and 41010).en_US
dc.identifier.citationKatanić, J., Ceylan, R., Matić, S., Boroja, T., Zengin, G., Aktümsek, A., Mihailović, V., Stanić, S. (2017). Novel perspectives on two digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation. South African Journal of Botany, 109, 50-57. doi: https://dx.doi.org/10.1016/j.sajb.2016.12.004
dc.identifier.doi10.1016/j.sajb.2016.12.004en_US
dc.identifier.endpage57en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2016.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35328
dc.identifier.volume109en_US
dc.identifier.wosWOS:000400465400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorCeylan, Ramazan
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHPLCen_US
dc.subjectDigitalisen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectAntigenotoxicen_US
dc.subjectYüksükotu
dc.subjectAntioksidan
dc.subjectAntimikrobiyal
dc.subjectAntijenotoksik
dc.titleNovel Perspectives on Two Digitalis Species: Phenolic Profile, Bioactivity, Enzyme Inhibition, and Toxicological Evaluationen_US
dc.typeArticleen_US

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