Effect of pentoxifylline on antioxidant status of healthy and endotoxemic New Zealand white rabbits

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dc.contributor.authorKeskin, E
dc.contributor.authorOztekin, E
dc.contributor.authorCol, R
dc.contributor.authorSivrikaya, A
dc.contributor.authorUney, K
dc.contributor.authorYazar, E
dc.date.accessioned2020-03-26T16:56:56Z
dc.date.available2020-03-26T16:56:56Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, effect of pentoxifylline on antioxidant status of healthy and endotoxemic rabbits was investigated. Endotoxemia was induced with E. coli lipopolysaccharide in New Zealand white rabbits. Forty rabbits were randomly divided into four equal groups. Group 1 served as control. Animals in Group 2 were given lipopolysaccharide (400 mu g/kg) intravenously, in Group 3 pentoxifylline (50 mg/kg) was injected intraperitoneally. In Group 4; pentoxifylline (50 mg/kg intraperitoneally) and lipopolysaccharide (400 mu g/kg, intravenously) were injected simultaneously. Animals were killed, and liver, heart and kidney samples were taken at 6 hours after administrations. Malondialdehyde, superoxide dismutase, glutathione peroxidase and reduced glutathione levels of heart, liver and kidney tissues were measured. Lipopolysaccharide caused significant increases (p < 0.05) in hepatic malondialdehyde, and cardiac, hepatic and renal glutathione peroxidase activities. It however, caused significant (P < 0.05) decrease in hepatic superoxide dismutase activity when compared to control group. Pentoxifylline caused significant (p < 0.05) increases of cardiac and hepatic malondialdehyde levels, cardiac superoxide dismutase and renal glutathione peroxidase activities, and cardiac, hepatic and renal reduced glutathione levels when compared to control group. As a result, pentoxifylline has no exactly beneficial effect on the antioxidant status of healthy and endotoxaemic New Zealand white rabbits at the administered dose and route. Although it was stated that pentoxifylline may be beneficial in endotoxaemia, its antioxidant effect may be dependent on dose, administration route and animal species. For this reason, when pentoxifylline is used in endotoxaemia, a treatment protocol should be done for each animal species.en_US
dc.identifier.doi10.2754/avb200574010017en_US
dc.identifier.endpage21en_US
dc.identifier.issn0001-7213en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://dx.doi.org/10.2754/avb200574010017
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19683
dc.identifier.volume74en_US
dc.identifier.wosWOS:000228165100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVETERINARNI A FARMACEUTICKA UNIVERZITA BRNOen_US
dc.relation.ispartofACTA VETERINARIA BRNOen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpentoxifyllineen_US
dc.subjectlipopolysaccharideen_US
dc.subjectantioxidant statusen_US
dc.subjectrabbitsen_US
dc.titleEffect of pentoxifylline on antioxidant status of healthy and endotoxemic New Zealand white rabbitsen_US
dc.typeArticleen_US

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