The prognostic value of serum troponin T in unstable angina

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dc.contributor.authorCin V.G.
dc.contributor.authorGök H.
dc.contributor.authorKaptano?lu B.
dc.date.accessioned2020-03-26T16:25:00Z
dc.date.available2020-03-26T16:25:00Z
dc.date.issued1996
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Cardiac troponin T is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. We used a newly developed enzyme immunoassay for troponin T to determine whether its presence in the serum of patients with unstable angina was a prognostic indicator. Methods: We screened 72 patients with unstable angina (Class III, acute unstable angina) for serum creatine kinase activity, creatine kinase myocardial band (isoenzyme M) activity, and troponin T, every 8 h for 2 days after admission to the hospital. The outcomes of interest during the hospitalization were death and myocardial infarction. Results: Troponin T was detected in the serum of 24 of the 72 patients (34%) with acute angina at rest. Only four of these patients had elevated creatine kinase M activity. Of the 24 patients who were positive for troponin T, 12 had myocardial infarction, and 6 of these died during hospitalization. In contrast, only 2 of the 48 patients with angina at rest who were negative for troponin T had an acute myocardial infarction, and these patients died. Thus, 12 of the 14 patients with myocardial infarctions had detectable levels of troponin T; only 2 had elevated creatine kinase M activity. Conclusions: Cardiac troponin T in serum appears to be a more sensitive indicator of myocardial-cell injury than serum creatine kinase MB activity, and its detection in the circulation may be a useful prognostic indicator in patients with unstable angina.en_US
dc.identifier.doi10.1016/0167-5273(95)02532-4en_US
dc.identifier.endpage244en_US
dc.identifier.issn0167-5273en_US
dc.identifier.issue3en_US
dc.identifier.pmid8793576en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.1016/0167-5273(95)02532-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16466
dc.identifier.volume53en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTroponin Ten_US
dc.subjectUnstable anginaen_US
dc.titleThe prognostic value of serum troponin T in unstable anginaen_US
dc.typeArticleen_US

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