Asymmetric dimethylarginine levels in Behcet's disease

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dc.contributor.authorOzturk, Bahadir
dc.contributor.authorVatansev, Husamettin
dc.contributor.authorTaner, Alpaslan
dc.contributor.authorYilmaz, Sema
dc.contributor.authorDagli, Mehmet
dc.contributor.authorUnlu, Ali
dc.date.accessioned2020-03-26T18:49:31Z
dc.date.available2020-03-26T18:49:31Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Behcet's disease (BD) is a chronic, inflammatory, multisystem vasculitis and the etiology is not yet fully understood. Nitric Oxide (NO) is an important molecule for the vascular system which synthesised by the Nitric Oxide Synthase (NOS) enzyme. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. Therefore, we aimed to investigate levels of the ADMA and its relation with exacerbations in BD patients. Methods: The subjects enrolled in this study were recruited from 34 patients with BD and 34 healthy controls. Serum levels of ADMA, arginine and citrulline were measured by HPLC with fluorescence detection. The ESR and CRP levels analyzed by routinely used methods. Results: In contrast to information in the literature, ADMA levels were found to be decreased in BD patients when compared to control. Inversely, Arginine and Citrulline levels were significantly increased in BD patients. Increased Arginine/ADMA ratios were found in the patient group. There was an inverse relation between ADMA and CRP levels. Arginine values were also correlated CRP and Citrulline levels. Conclusion: One of the reasons of high number of BD attacks in young age may be low levels of ADMA. Our study suggests that the reduced levels of ADMA in patients group may impose a possible preventive role to ADMA through decrease of NO-mediated inflammation and exacerbations of BD with aging.en_US
dc.identifier.doi10.5505/tjb.2014.74436en_US
dc.identifier.endpage367en_US
dc.identifier.issn0250-4685en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://dx.doi.org/10.5505/tjb.2014.74436
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30629
dc.identifier.volume39en_US
dc.identifier.wosWOS:000346148200016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsymmetric dimethylarginine (ADMA)en_US
dc.subjectBehcet's disease (BD)en_US
dc.subjectNitric oxide (NO)en_US
dc.subjectVasculitisen_US
dc.titleAsymmetric dimethylarginine levels in Behcet's diseaseen_US
dc.typeArticleen_US

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