Assessment of serum ischemia-modified albumin, prolidase and thiol-disulphide levels in subjects with breast cancer.

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dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorEryavuz, Duygu
dc.contributor.authorBal, Ceylan
dc.contributor.authorNural, Cemil
dc.contributor.authorÖzcan, Erel
dc.contributor.authorYıldırımel, Mehmet
dc.contributor.authorÇelik, Saadet
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2020-03-26T20:12:38Z
dc.date.available2020-03-26T20:12:38Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Oxidative damage is of great importance for patients with breast cancer. Thus, studies were performed to identify the relationship between breast cancer and oxidative stress biomarkers. Objectives: In this study, our aim was to find out the oxidative and antioxidant status, serum thiol-disulphide levels in subjects with breast cancer. Methods: This study was conducted between March and June 2018 with 82 control subjects (aged between 3267 years) and 127 breast cancer patients (aged between 27-66 years) (p= 0.058) in Selcuk University Faculty of Medicine, Konya, Turkey. Serum myeloperoxidase (MPO), catalase, prolidase were analyzed with kinetic spectrophotometric and thiol-disulphide, ischemia-modified albumin (IMA), ceruloplasmin were detected by colorimetric methods. Results: Serum levels of catalase [199.3 (16.4-489.9) vs 81.6 (18.2-322.9) (kU/L)], MPO [124 +/- 28 vs 101 +/- 31 U/L], disulphide [25 (11-61) vs 18 (2-41) mu mol/L], IMA [0.66 (0.31-3.30) vs 0.62 (0.19-1.31) absorbance unit (ABSU)] and prolidase levels [2217 +/- 538 vs 1456 +/- 401 U/L] were higher in patients than control subjects (For all p< 0.001 except for IMA p=0.031). Native thiol [342 +/- 60 vs 391 +/- 52 mu mol/L] and total thiol levels [396 +/- 56 vs 430 +/- 52 mu mol/L] were lower in patients compared with the control group (For all p< 0.001). Conclusions: Levels of serum thiol/disulphide and prolidase might be reliable indicators for determining oxidative status in certain patient populations.en_US
dc.identifier.citationAbusoglu, S., Eryavuz, D., Bal, C., Nural, C., Ozcan, E., Yildirimel, M., Celik, S., Unlu, A. (2019). Assessment of Serum Ischemia-modified albumin, Prolidase and Thiol- Disulphide Levels in Subjects With Breast Cancer. Revista Romana de Medicina de Laborator, 27(1), 25-33.
dc.identifier.doi10.2478/rrlm-2019-0013en_US
dc.identifier.endpage33en_US
dc.identifier.issn1841-6624en_US
dc.identifier.issn2284-5623en_US
dc.identifier.issue1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://dx.doi.org/10.2478/rrlm-2019-0013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37508
dc.identifier.volume27en_US
dc.identifier.wosWOS:000456448100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorAbuşoğlu, Sedat
dc.institutionauthorEryavuz, Duygu
dc.institutionauthorYıldırımel, Mehmet
dc.institutionauthorÜnlü, Ali
dc.language.isoenen_US
dc.publisherUNIV PRESSen_US
dc.relation.ispartofREVISTA ROMANA DE MEDICINA DE LABORATORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbreast canceren_US
dc.subjectischemia modified albuminen_US
dc.subjectoxidative stressen_US
dc.subjectprolidaseen_US
dc.subjectthiol-disulphideen_US
dc.titleAssessment of serum ischemia-modified albumin, prolidase and thiol-disulphide levels in subjects with breast cancer.en_US
dc.typeArticleen_US

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