Disposition and milk levels of sulfadiazine-trimethoprim combination following intrauterine bolus administration in lactating cows during postpartum

Basit Öğe Kaydı
dc.contributor.authorElmas, M
dc.contributor.authorTras, B
dc.contributor.authorBas, AL
dc.contributor.authorYazar, E
dc.contributor.authorNizamlioglu, F
dc.contributor.authorColak, M
dc.contributor.authorYapar, K
dc.date.accessioned2020-03-26T16:27:06Z
dc.date.available2020-03-26T16:27:06Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was carried out to describe the disposition and milk levels of sulfadiazine (SDZ)-trimethoprim (TMP) combination following intrauterine bolus administration in cows during postpartum. Six cows were used as materials. SDZ-TMP combination bolus was given through intrauterine administration at the recommended dose of 4 g of SDZ plus 0.8 g of TMP to each animal during postpartum. Concentrations of SDZ and TMP were determined by HPLC. The absorption half-lives of SDZ and TMP were 1.44 and 1.68 hours, respectively. The elimination half-life of SDZ was 3.74 hours, while it was 11.04 hours for TMP. SDZ did not reach to MIC levels in plasma and milk after the intrauterine administration. After intrauterine administration, TMP was detected at the effective levels in milk. These results suggest that passing ratio of antimicrobials into milk should be taken into consideration for drug administrations into uterine in lactating cows during postpartum.en_US
dc.identifier.endpage894en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage891en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16943
dc.identifier.volume150en_US
dc.identifier.wosWOS:000084395000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONAL VET TOULOUSEen_US
dc.relation.ispartofREVUE DE MEDECINE VETERINAIREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsulfadiazineen_US
dc.subjecttrimethoprimen_US
dc.subjectbolusen_US
dc.subjectintrauterin administrationen_US
dc.titleDisposition and milk levels of sulfadiazine-trimethoprim combination following intrauterine bolus administration in lactating cows during postpartumen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu