The Effects of One Dose and Seven Days' Managements of Melatonin and Steroid to Prevent Ischemia-Reperfusion Injury in Testicular Torsion

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dc.authorid0000-0002-5783-7181
dc.authorid0000-0002-6638-521X
dc.authorid0000-0002-8709-8949
dc.authorid0000-0003-2053-4969
dc.contributor.authorYurtçu, Müslim
dc.contributor.authorAbasıyanık, Adnan
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorKaragözoğlu, Emrah
dc.contributor.authorAbasıyanık, Fatma
dc.date.accessioned2020-03-26T16:58:38Z
dc.date.available2020-03-26T16:58:38Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesi, Meram Tıp Fakültesi, Çocuk Cerrahisien_US
dc.departmentSelçuk Üniversitesi, Meram Tıp Fakültesi, Patoloji
dc.description.abstractObjective: The aim of the study is to determine the effects of melatonin and steroid treatments which were injected as one-dose and one-dose for seven days to prevent ischemia-reperfusion injury occurred in testicle after torsion and detorsion and which of these treatments is more effective. Material and Methods: Eighty prepubertal male Sprague-Dawley rats were devided into 8 groups each containing 10 rats. In all groups, except sham groups, torsion was created by rotating the left testicles 720° in a clockwise direction for 6 hours. In melatonin groups 17 mg/kg melatonin and in steroid groups 1 mg/kg methylprednesolone were injected before 30 minutes from detorsion. In seven dose steroid and melatonin groups melatonin and methylprednesolone were injected once a day for 7 days. In Sham-1, torsion-detorsion-1, one-dose melatonin and, one-dose steroid groups left orchiectomies were created after 6 hours of detorsion. In other group, left orchiectomies were performed 7 days later. After performing histopathologic examination we determined MDA levels and Johnsen's scores of testicular tissue to identify ischemia-reperfusion injury. Results: MDA levels in one-dose melatonin and steroid groups were significantly less compared with torsion-detorsion-1 group (p < 0.05). Johnsen's scores were the same as in one-dose melatonin, steroid and torsion-detorsion-1 groups (p > 0.05). It was identified that MDA levels in seven dose melatonin and seven dose steroid groups were significantly less compared with torsion-detorsion-2 group (p < 0.01) and Johnsen's scores were significantly higher compared with torsion-detorsion-2 group (p < 0.01). Conclusion: The treatments of one-dose melatonin and steroid are effective against the I-R damage biochemically, but not histopathologically. Whereas, melatonin and steroid, which were injected once a day for 7 days, prevent ischemia-reperfusion injury completely. Copyright © 2005 by Türkiye Klinikleri.en_US
dc.identifier.endpage500en_US
dc.identifier.issn1300-0292en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19992
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYurtçu, Müslim
dc.institutionauthorAbasıyanık, Adnan
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTürkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMelatoninen_US
dc.subjectReperfusion injuryen_US
dc.subjectSpermatic cord torsionen_US
dc.subjectSteroidsen_US
dc.titleThe Effects of One Dose and Seven Days' Managements of Melatonin and Steroid to Prevent Ischemia-Reperfusion Injury in Testicular Torsionen_US
dc.title.alternativeTestis Torsiyonundaki İskemi-Reperfüzyon Hasarını Önlemede Melatonin ve Steroidin Tek Doz ve Yedi Günlük Tedavilerinin Etkilerien_US
dc.typeArticleen_US

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