Lotus aegaeus (Gris.) Boiss and lberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems

Basit Öğe Kaydı
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorVlaisavljevic, Sanja
dc.contributor.authorBerezni, Sanja
dc.contributor.authorAbdallah, Hassan Hadi
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAtanasov, Atanas G.
dc.contributor.authorMollica, Adriano
dc.date.accessioned2020-03-26T19:54:35Z
dc.date.available2020-03-26T19:54:35Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractNatural products are gaining much momentum worldwide because they have a broad spectrum of biological effects and present excellent opportunities for bioproducts development. With this fact, this study has been designed to investigate for the first time the effects of the ethyl acetate (EA), methanolic (MeOH), and water (W) extracts of Lotus aegaeus (La) and Iberis sempervirens (Is) on key enzymes as well as to quantify antioxidant capacities. The total phenolic and flavonoid content were determined using colorimetric methods and the individual phenolic compounds were assessed by LC-MS/MS analysis. Quercetin hexoside was the dominant compound in L. aegaeus, particularly in methanol extract, while the ethyl acetate and methanol extracts of I. sempervirens were characterized by the presence scopoletin and hinic acid. The antioxidant abilities of the investigated extracts were tested using different assays including free radical scavenging, reducing power, phosphomolybdenum, and metal chelating. All the extracts showed strong antioxidant abilities. For both species, the ethyl acetate extracts were more potent against cholinesterases and alpha-amylase, while the methanol extracts were most active against a-glucosidase. Only the water extract, followed by methanol of L sempervirens exhibited notable inhibitory activity against tyrosinase. In addition, the dominant compounds were docked against tyrosinase and a-glucosidase to investigate their predicted binding affinity and interactions with the active site. In conclusion, L. aegaeus and I. sempervirens showed potent biological attributes, which advocates for further studies to explore their potential use as phytopharmaceuticals.en_US
dc.identifier.doi10.1016/j.indcrop.2018.04.056en_US
dc.identifier.endpage278en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.04.056
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36759
dc.identifier.volume120en_US
dc.identifier.wosWOS:000434745000031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPolyphenolsen_US
dc.subjectAntioxidantsen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectMedicinal plantsen_US
dc.subjectPharmaceuticalsen_US
dc.subjectMolecular dockingen_US
dc.titleLotus aegaeus (Gris.) Boiss and lberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problemsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu