First Case of Hepatitis B Virus Genotype H Infection in Turkey

Basit Öğe Kaydı
dc.contributor.authorUral, Onur
dc.contributor.authorSayan, Murat
dc.contributor.authorAkhan, Sıla
dc.contributor.authorSümer, Sua
dc.contributor.authorŞimşek, Funda
dc.date.accessioned2020-03-26T18:41:59Z
dc.date.available2020-03-26T18:41:59Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractClinical studies reported from Turkey indicate that hepatitis B virus (HBV) genotype D is more prevalent than other genotypes. Epidemiological and clinical information on genotype H infection is currently limited. Genotype H infection is most likely due to its regional (Central and South America) prevalence throughout the world. The aim of this report is to present the first HBV genotype H infection in a chronic hepatitis B patient in Turkey. Laboratory findings of a 42 years old male patient admitted to our hospital revealed HBsAg (+), anti-HBs (-), HBeAg (-), anti-HBe (+), anti-HBc IgM (-), anti-HBc IgG (+), anti-HAV IgG (+), HBV-DNA: 5.689.776 IU/ml and high liver enzymes (ALT: 223 U/L, AST: 121 U/L). History of the patient indicated no risk factor (intravenous drug use, blood transfusion, suspicious sexual contact) related to HBV transmission. Since liver ultrasonography showed multiple hemangiomas, biopsy was performed and histologic activity index was found as 6/18 and fibrosis as 2/6, according to modified Knodell score system. HBV DNA isolated from the serum sample of the patient was amplified by polymerase chain reaction and polynnerase gene segment of HBV was directly sequenced. UPGMA method was used for phylogenetic analysis, and the genotype of the virus was identified accordingly. The nucleotide sequence was compared to those from the international DNA data bank (GenBank). The genotyping of the patient revealed that the isolated HBV was genotype H. Treatment with tenofovir disoproxil fumarate was initiated and the patient responded to the treatment. This finding suggested that other HBV genotypes, except the predominant genotype D may also be in circulation in Turkey. In conclusion, detection of epidemiologic and molecular characteristics of HBV genotype H which is related to chronic hepatitis, seems to be necessary in order to better understand its circulation and progression around the world.en_US
dc.identifier.endpage555en_US
dc.identifier.issn0374-9096en_US
dc.identifier.issue3en_US
dc.identifier.pmid23971934en_US
dc.identifier.startpage550en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29521
dc.identifier.volume47en_US
dc.identifier.wosWOS:000324607700017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherANKARA MICROBIOLOGY SOCen_US
dc.relation.ispartofMIKROBIYOLOJI BULTENIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHepatitis B virusen_US
dc.subjectHBV genotype Hen_US
dc.subjectTurkeyen_US
dc.titleFirst Case of Hepatitis B Virus Genotype H Infection in Turkeyen_US
dc.typeArticleen_US

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