The Correlation between the Level of Doxorubicin-Induced Cardiac Damage and Serum Soluble Fas in an Experimental Rat Model

Basit Öğe Kaydı
dc.contributor.authorKose, Dogan
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorCelik, Zeliha Esin
dc.contributor.authorUnlu, Ali
dc.contributor.authorArtac, Hasibe
dc.contributor.authorKoksal, Yavuz
dc.date.accessioned2020-03-26T19:55:56Z
dc.date.available2020-03-26T19:55:56Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: This study was planned to research the relationship between doxorubicin cardiomyopathy and the soluble Fas (sFas) level. Materials and Methods: Two groups of rats were included in the study. The control group was given physiological saline, while the study group was given doxorubicin. The rats, whose blood samples were taken weekly, were sacrificed and their myocardial tissues were removed. The tissues were examined in terms of morphological changes and surface Fas expression, while the blood samples were examined in terms of sFas level. Results: In the study group, the sFas levels at 2nd-9th weeks were higher than those found at 1st week before administrating the drug, and the increase at 2nd-7th weeks was meaningful. In addition, sFas levels were gradually increased each week during 1st-5th weeks when compared to the values of a previous week, and the increase during the first 4 weeks was meaningful. After the 5th week, the values gradually decreased each week. The mean values of the study group at 1st-8th weeks were higher than those of the control group, and the increases at 2nd-8th weeks were meaningful. The severe forms of interfibrillar hemorrhage, vascular dilatation, myocardial necrosis, inflammatory infiltration, and splitting of muscle fibers occurred with 15, 15, 17.5, 20, and 22.5 mg/kg dose of medicine, respectively. Conclusions: As the tissue injury increased, the increasing cell-surface Fas expression and sFas plasma level at the acute phase of doxorubicin-related cardiotoxicity decreased. The sFas level determined at acute phase may be helpful in predicting the existing injuries and possible late-term problems.en_US
dc.identifier.doi10.4103/ijmpo.ijmpo_82_17en_US
dc.identifier.endpage478en_US
dc.identifier.issn0971-5851en_US
dc.identifier.issn0975-2129en_US
dc.identifier.issue4en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage473en_US
dc.identifier.urihttps://dx.doi.org/10.4103/ijmpo.ijmpo_82_17
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36988
dc.identifier.volume39en_US
dc.identifier.wosWOS:000450295100011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.ispartofINDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCardiacen_US
dc.subjectdoxorubicinen_US
dc.subjectfasen_US
dc.subjectraten_US
dc.titleThe Correlation between the Level of Doxorubicin-Induced Cardiac Damage and Serum Soluble Fas in an Experimental Rat Modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu