Dispeptik hastalarda H. pylori infeksiyonu tanısında H. pylori gaita antijeninin tanı değerinin incelenmesi
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Tarih
2005
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Dünyadaki en yaygın infeksiyonlarından biri olan Helicobacter pylori infeksiyonu yaşamın ilk yıllarında alınmakta ve tedavi edilmedikçe hayat boyu devam etmektedir. H. pylori, çocuk ve yetişkinlerde kronik gastrit ve peptik ülser hastalığının ana etkenidir ve MALT lenfoma ve mide kanserinde risk faktörüdür. Bu çalışmanın amacı, H. pylori infeksiyonu tanısında histopatoloji, hızlı üreaz testi, üre soluk testi gibi testler ile karşılaştırarak H. pylori gaita antijen (HpSA)’nin tanı değerini araştırmaktır. Yöntem: Bu çalışmada; hastanemizin endoskopi ünitesine Mart 2003 ile Mart 2004 tarihleri arasında gastrointestinal sistem şikayetleri nedeniyle endoskopi yapılmak üzere başvuran 103 hasta çalışmaya alındı. Bulgular: Çalışmaya aldığımız yüz üç hastanın 66’sı H. pylori infeksiyonu yönünden pozitif (% 64) iken 37’si negatifti (% 36). HpSA testi pozitif olması gereken 66 testten 58’ini pozitif olarak bulurken, negatif olarak beklenen 37 testten 35’ini negatif tespit etti. HpSA testinin sensitivite, spesifite, pozitif prediktif değer ve negatif prediktif değerleri sırasıyla % 87.9, % 94.6, % 96.7 ve % 81.4 bulundu. Sonuç: HpSA testleri noninvasiv, H. pylori infeksiyonunda kullanması kolay, ucuz ve serolojik antikor testleri yerine kullanılması önerilebilir testlerdir.
Objective: H. pylori infection which is the most common infection in the world is acquired in early childhood and usually persists throughout life unless a specific treatment applied. H. pylori infection is the major cause of chronic gastritis and peptic ulcer disease in both adult and children and it is a risk factor for the development of mucosa associated lymphoid tissue lymphoma and gastic carcinoma. The aim of this study was to evaluate the usefulness of HpSA in diagnosis of H. pylori infection in patients comparison with other methods like histology, rapid urease test and urea breath test. Method: 103 patients referred to endoscopy unit for routine gastrointestinal endoscopy for the evaluation of dyspeptic complaints, between March 2003 and March 2004 were included in this study. Results: Sixty-six of the 103 patients (64%) were positive for H. pylori, whereas 37 of patients (36%) were negative. HpSA was positive in 58 of 66 and negative in 35 of 37. The sensitivity, specificity, positive predictive value, and negative predictive value of the methods of HpSA was 87.9%, 94.6%, 96.7%, and 81.4%, respectively. Conclusion: HpSA test is cheap, easy, noninvasive test that is advisable for using instead of serological antibody tests.
Objective: H. pylori infection which is the most common infection in the world is acquired in early childhood and usually persists throughout life unless a specific treatment applied. H. pylori infection is the major cause of chronic gastritis and peptic ulcer disease in both adult and children and it is a risk factor for the development of mucosa associated lymphoid tissue lymphoma and gastic carcinoma. The aim of this study was to evaluate the usefulness of HpSA in diagnosis of H. pylori infection in patients comparison with other methods like histology, rapid urease test and urea breath test. Method: 103 patients referred to endoscopy unit for routine gastrointestinal endoscopy for the evaluation of dyspeptic complaints, between March 2003 and March 2004 were included in this study. Results: Sixty-six of the 103 patients (64%) were positive for H. pylori, whereas 37 of patients (36%) were negative. HpSA was positive in 58 of 66 and negative in 35 of 37. The sensitivity, specificity, positive predictive value, and negative predictive value of the methods of HpSA was 87.9%, 94.6%, 96.7%, and 81.4%, respectively. Conclusion: HpSA test is cheap, easy, noninvasive test that is advisable for using instead of serological antibody tests.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Helicobacter pylori
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
15
Sayı
2
