Protective effects of caffeic acid phenethyl ester, ellagic acid, sulforaphan and curcuma on malathion induced damage in lungs, liver and kidneys in an acute toxicity rat model

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dc.contributor.authorAlp, Harun
dc.contributor.authorAytekin, İsmail
dc.contributor.authorEsen, Hasan
dc.contributor.authorAlp, Ayşe
dc.contributor.authorBüyükbaş, Sadık
dc.contributor.authorBaşaralı, Kemal
dc.contributor.authorHatipoğlu, Namık Kemal
dc.date.accessioned2020-03-26T18:15:50Z
dc.date.available2020-03-26T18:15:50Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphan (SFN) and curcuma (CUR) against acute malathion (MAL) poisoning in rats. For that, 60 female adult Sprague-Dawley rats were randomly divided into 10 equal groups according to the treatment: whereas one group served as unmedicated control and another was intoxicated with malathion (200 mg/kg, per ox) and served as positive control, rats from the other groups were treated with each of the four antioxidants (CAPE: 10 mu mol/kg, intraperitoneally, EA: 85 mg/kg, per ox, SFN: 0.5 mg/kg, per os and CUR: 1 g/kg, per os) alone or in combination with malathion. One day later, serum AChE (acetylcholinesterase), amylase and GGT (gamma-glutamyltransferase) activities were determined and a histopathological evaluation was performed on lungs, kidneys and liver. In MAL-intoxicated rats, the AChE activity was markedly depleted whereas the GOT and amylase activities were significantly increased compared to the unmedicated controls. In parallel, severe and extended inflammatory and degenerative cell lesions were evidenced in liver, kidneys and lungs. By contrast, changes in the serum enzyme activities were greatly attenuated and the organ damage was also markedly reduced but not completely abrogated when an antioxidant cotreatment has been instituted. In addition, CUR appeared as the more efficient for hindering biochemical and histopathological alterations induced by malathion. These results show the protective effects of CAPE, EA, SFN and CUR on acute malathion poisoning in rats.en_US
dc.identifier.endpage340en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issn2258-0646en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26761
dc.identifier.volume162en_US
dc.identifier.wosWOS:000295892300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONALE VETERINAIRE TOULOUSEen_US
dc.relation.ispartofREVUE DE MEDECINE VETERINAIREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMalathionen_US
dc.subjecttoxicityen_US
dc.subjectraten_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectcurcumaen_US
dc.subjectellagic aciden_US
dc.subjectsulforaphanen_US
dc.subjectantioxidanten_US
dc.subjectliveren_US
dc.subjectkidneyen_US
dc.subjectlungen_US
dc.subjectacetyl-cholinesteraseen_US
dc.subjectamylaseen_US
dc.subjectgamma-glutamyltransferaseen_US
dc.titleProtective effects of caffeic acid phenethyl ester, ellagic acid, sulforaphan and curcuma on malathion induced damage in lungs, liver and kidneys in an acute toxicity rat modelen_US
dc.typeArticleen_US

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