Examination of the effects of different phosphodiesterase type 5 enzyme inhibitors on the isolated rat myometrium contraction

Basit Öğe Kaydı
dc.contributor.authorKaçar, Doğan
dc.contributor.authorBaltacı, Abdulkerim Kasım
dc.contributor.authorAyar, Ahmet
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T19:53:54Z
dc.date.available2020-03-26T19:53:54Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study aims to explore the effects of the phosphodiesterase inhibitors tadalafil and vardenafil on the spontaneous contractions of isolated rat myometrium. The study included 45 virgin female rats weighing between 250 and 260 g. Two different agents were used in two different tissue cross-sections taken from each animal. Spontaneous contractions as well as the contractions following tadalafil and vardenafil applications (200, 400, and 600 mu l) in the tissue preparations, were evaluated in 10 minute periods in terms of frequency, amplitude, and the area under the contraction curve. Isometric contractions were measured and evaluated on the oscillographic records. The highest tadalafil dose (600 mu l) significantly reduced frequency in comparison to control values (p<0.01). Vardenafil did not produce any effect on contraction frequency. When the effects of the agents on contraction amplitude were evaluated, the highest dose of tadalafil was again found to lead to a significant drop in the amplitude (p<0.05). The same dose of tadalafil was also seen to markedly decrease the area under the curve (p<0.05). Results of the study indicate that tadalafil markedly inhibits the frequency, amplitude, and area under the contraction curve, all of which are isolated myometrial contraction parameters in rats, in a dose-dependent manner. However, vardenafil did not produce any effect on these parameters.en_US
dc.identifier.endpage3240en_US
dc.identifier.issn2069-5837en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3237en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36617
dc.identifier.volume8en_US
dc.identifier.wosWOS:000435601200013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBIOINTERFACE RESEARCH APPLIED CHEMISTRYen_US
dc.relation.ispartofBIOINTERFACE RESEARCH IN APPLIED CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMyometrial contractionsen_US
dc.subjecttadalafilen_US
dc.subjectvardenafilen_US
dc.subjectraten_US
dc.titleExamination of the effects of different phosphodiesterase type 5 enzyme inhibitors on the isolated rat myometrium contractionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu