Exploring chemical profiles and bioactivities of Harungana madagascariensis Lam. ex Poir. leaves and stem bark extracts: A new source of procyanidins

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dc.contributor.authorLiorent-Martinez, Eulogio J.
dc.contributor.authorRuiz-Riaguas, Alba
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorBene, Kouadio
dc.contributor.authorCordova, Maria Luisa Fernandez-de
dc.contributor.authorPicot-Allain, Carene
dc.contributor.authorMahomoodally, Fawzi ‪Mohamad
dc.contributor.authorSaleem, Hammad
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:20:16Z
dc.date.available2020-03-26T20:20:16Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis study attempts to valorize the multiple pharmacological properties of Harungana madagascariensis Lam. ex Poir., also known as dragon's blood tree, with wide applications in African traditional medicine. The antioxidant and inhibitory activity of H. madagascariensis leaves and stem bark extracts (ethyl acetate, aqueous extracts, and methanol) against enzymes related to diabetes (alpha-glucosidase, alpha-amylase), epidermal hyperpigmentation problems (tyrosinase), and Alzheimer's disease (acetyl and butyryl cholinesterase) were evaluated. The phytochemical profiles of the extracts were studied by high-performance liquid chromatography with diode array detection and mass spectrometry (HPLC-DAD-MS), observing the presence of procyanidins and flavonoids, particularly in the leaves' extracts. The radical scavenging and reducing power of H. madagascariensis leaves' extracts were greater than the stem bark extracts. The methanol extracts of leaves (4.61 mg galantamine equivalent (GALAE)/g extract) and stem bark (4.68 mg galantamine (GALAE)/g extract) of H. madagascariensis inhibited acetyl cholinesterase. Methanol extracts (153.55 and 147.07 mg kojic acid equivalent (KAE)/g extract, for leaves and stem bark extracts, respectively) of H. madagascariensis showed high tyrosinase inhibition. Correlation and principal component analysis (PCA) were also performed. The observed pharmacological effects of H. madagascariensis support that this plant may be a promising candidate for the development of novel pharmacophores for the treatment of diabetes, epidermal hyperpigmentation problems, Alzheimer's disease, and other oxidative-stress-related complications.en_US
dc.identifier.citationLiorent-Martinez, E. J., Ruiz-Riaguas, A., Sinan, K. I., Bene, K., Fernández-de Cordova, M. L., Picot-Allain, C., Mahomoodally, F. M., Saleem, H., Zengin, G. (2020). Exploring Chemical Profiles and Bioactivities of Harungana madagascariensis Lam. ex Poir. Leaves and Stem Bark Extracts: A New Source of Procyanidins. Analytical Letters, 53(3), 399-412.
dc.identifier.doi10.1080/00032719.2019.1653903en_US
dc.identifier.endpage412en_US
dc.identifier.issn0003-2719en_US
dc.identifier.issn1532-236Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage399en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00032719.2019.1653903
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38545
dc.identifier.volume53en_US
dc.identifier.wosWOS:000482167700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSinan, Kouadio Ibrahime
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofANALYTICAL LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectDiabetesen_US
dc.subjecthigh-performance liquid chromatography with diode array and mass spectrometry detection (HPLC-DAD-MS)en_US
dc.subjectPhenolicen_US
dc.subjectPrincipal component analysisen_US
dc.titleExploring chemical profiles and bioactivities of Harungana madagascariensis Lam. ex Poir. leaves and stem bark extracts: A new source of procyanidinsen_US
dc.typeArticleen_US

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