Evaluation of TGF beta 1 expression and comparison the thickness of different aorta layers in experimental diabetes

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dc.contributor.authorCuce G.
dc.contributor.authorKalkan S.S.
dc.contributor.authorEsen H.H.
dc.date.accessioned2020-03-26T18:22:14Z
dc.date.available2020-03-26T18:22:14Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: It was aimed to investigate the effects of experimental diabetes on TGF ß1 expression and tunica intima and media thickness in abdominal and thoracic aorta. Methods: Fourteen three months old female rats were divided into two groups, non-diabetic and streptozotocin (STZ) induced diabetic group. Hematoxylin-Eosin and Verhoeff's Van Gieson elastic staining and TGF ß1 im-munohistochemistry staining were performed. Abdominal and thoracic intima and media thickness of aortas were measured with the oculometer. Results: Evaluation of intima and media thickness measurements showed no significant statistical differences between non-diabetic and diabetic groups. TGF ß1 expression increased significantly in thoracic diabetic (TD) group. Conclusion: The 60 day duration of diabetes is not sufficiently enough time for the development of pathological changes that could lead to thickening in aortic intima-media layers. TGF ß1 expression was negative in the abdominal aorta that can predispose to the development of atherosclerosis, which could develop overtime. This finding may be interpreted as an appropriate basis for the development of atherosclerosis. In the thoracic aorta TGF ß1 may coordinate cellular events such as tissue repair.en_US
dc.identifier.endpage322en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issue6en_US
dc.identifier.pmid21692405en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27230
dc.identifier.volume112en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAortaen_US
dc.subjectDiabetesen_US
dc.subjectIntima-media thicknessen_US
dc.subjectTGF ß1en_US
dc.titleEvaluation of TGF beta 1 expression and comparison the thickness of different aorta layers in experimental diabetesen_US
dc.typeArticleen_US

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