Effects of selective iNOS inhibition in sepsis: Evaluation of lung tissue damage and blood gases

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dc.contributor.authorCeran S.
dc.contributor.authorErikoglu M.
dc.contributor.authorSahin M.
dc.contributor.authorSunam G.S.
dc.contributor.authorGölcük M.
dc.contributor.authorPasao?lu H.
dc.contributor.authorAvsar F.
dc.date.accessioned2020-03-26T17:28:53Z
dc.date.available2020-03-26T17:28:53Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractNO is an important mediator in the generalized inflammatory response of the body during sepsis and septic shock. We investigated the possible effects of L-arginine and aminoguanidine on plasma NO levels and the interaction between NO levels and lung tissue damage and blood gases in sepsis. Fifty Wistar male rats were used in this study and divided into five groups: group 1, sham group; group 2, CLP (sepsis); group 3, CLP + 10 mg/kg L-arginine administration; group 4, CLP +15 mg/kg aminoguanidine administration; group 5: CLP + L-arginine + aminoguanidine given in similar doses. Sepsis was induced by cecal ligation and puncture (CLP) method. Drugs were administered at postoperative hours 4 and 12. The levels in the aminoguanidine and aminoguanidine + L-arginine groups were similar to the sham group. Lung tissue damage in the sepsis and L-arginine groups was more severe than the other groups.en_US
dc.identifier.endpage24en_US
dc.identifier.issn0020-8868en_US
dc.identifier.issue1en_US
dc.identifier.pmid18543550en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22868
dc.identifier.volume93en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofInternational Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAminoguanidineen_US
dc.subjectL-arginineen_US
dc.subjectLung tissue damageen_US
dc.subjectNitric oxideen_US
dc.subjectSepsisen_US
dc.titleEffects of selective iNOS inhibition in sepsis: Evaluation of lung tissue damage and blood gasesen_US
dc.typeArticleen_US

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