Direct enantioselective aldol reactions catalyzed by calix[4]arene-based L-proline derivatives in the water
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Two novel p-tert-butylcalix[4]arene-based chiral organocatalysts derived from L-proline have been developed to catalyze direct aldol reactions between cyclohexanone and aromatic aldehydes in water. Under the optimal conditions, high yields (up to 95%), enantioselectivities (up to 90%), and moderate diastereoselectivities (up to 65:35) were obtained. Considering the catalytic inefficiency of sole proline for the aldol reaction in water, these results clearly display the enormous effect of the hydrophobic part of calix[4]arene of compound A. (C) 2014 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Calix[4]arene, Organocatalysis, Aldol, Water
Kaynak
TETRAHEDRON
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
70
Sayı
30
