EFFECT OF DEXMEDETOMIDINE ON PAIN CAUSED BY INJECTION OF PROPOFOL
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NOBEL ILAC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: This study was designed to assess the local and systemic effects of two different pre-anesthetic infusion dose of dexmedetomidine in preventing propofol injection pain. Material and Method: Two hundred fifty adults were assigned into five groups. Before injection of propofol, group 1 (placebo n=50) received an infusion of saline solution, group 2 (n=50) received 0.5 mu g kg(-1) of dexmedetomidine and group 3 (n=50) received 1 mu g kg(-1) of dexmedetomidine from the same vein. Group 4 (n=50) received 0.5 mu g kg(-1) of dexmedetomidine and group 5 (n=50) received 1 mu g kg(-1) dexmedetomidine followed by an injection of propofol from a vein located in the opposite hand. Pain assessment was made immediately after propofol injection. Results: Two hundred twenty five patients completed the study. The number of patients who suffered from any degree of pain was significantly high when compared to dexmedetomidine group (p=0.05). When compared with placebo and opposite hand, administering dexmedetomidine from the same vein was more efficient to prevent propofol pain (p=0.003). 1 mu g kg(-1) of dexmedetomidine was similar to 0.5 mu g kg(-1) of dexmedetomidine in preventing propofol pain. Conclusion: Dexmedetomidine infusions in p re-anesthetic sedative doses of 0.5 mu g kg(-1) and 1 mu g kg(-1) decrease the incidence of propofol injection pain compared to placebo.
Açıklama
Anahtar Kelimeler
Dexmedetomidine, propofol, pain
Kaynak
NOBEL MEDICUS
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
8
Sayı
1
