EFFECT OF DEXMEDETOMIDINE ON PAIN CAUSED BY INJECTION OF PROPOFOL

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dc.contributor.authorSarkilar, Gamze
dc.contributor.authorKara, Inci
dc.contributor.authorDuman, Ates
dc.contributor.authorAygin, Feride
dc.contributor.authorOkesli, Selmin
dc.date.accessioned2020-03-26T18:24:58Z
dc.date.available2020-03-26T18:24:58Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: This study was designed to assess the local and systemic effects of two different pre-anesthetic infusion dose of dexmedetomidine in preventing propofol injection pain. Material and Method: Two hundred fifty adults were assigned into five groups. Before injection of propofol, group 1 (placebo n=50) received an infusion of saline solution, group 2 (n=50) received 0.5 mu g kg(-1) of dexmedetomidine and group 3 (n=50) received 1 mu g kg(-1) of dexmedetomidine from the same vein. Group 4 (n=50) received 0.5 mu g kg(-1) of dexmedetomidine and group 5 (n=50) received 1 mu g kg(-1) dexmedetomidine followed by an injection of propofol from a vein located in the opposite hand. Pain assessment was made immediately after propofol injection. Results: Two hundred twenty five patients completed the study. The number of patients who suffered from any degree of pain was significantly high when compared to dexmedetomidine group (p=0.05). When compared with placebo and opposite hand, administering dexmedetomidine from the same vein was more efficient to prevent propofol pain (p=0.003). 1 mu g kg(-1) of dexmedetomidine was similar to 0.5 mu g kg(-1) of dexmedetomidine in preventing propofol pain. Conclusion: Dexmedetomidine infusions in p re-anesthetic sedative doses of 0.5 mu g kg(-1) and 1 mu g kg(-1) decrease the incidence of propofol injection pain compared to placebo.en_US
dc.identifier.endpage88en_US
dc.identifier.issn1305-2381en_US
dc.identifier.issue1en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27936
dc.identifier.volume8en_US
dc.identifier.wosWOS:000303558300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNOBEL ILACen_US
dc.relation.ispartofNOBEL MEDICUSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDexmedetomidineen_US
dc.subjectpropofolen_US
dc.subjectpainen_US
dc.titleEFFECT OF DEXMEDETOMIDINE ON PAIN CAUSED BY INJECTION OF PROPOFOLen_US
dc.typeArticleen_US

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