Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous

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dc.contributor.authorAltan, Feray
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorAtik, Orkun
dc.contributor.authorUney, Kamil
dc.date.accessioned2020-03-26T19:55:00Z
dc.date.available2020-03-26T19:55:00Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, the pharmacokinetic disposition and bioavailability of marbofloxacin (MB) were determined in lambs after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at a dose of 3 mg/kg. The plasma concentration of MB was measured using high-performance liquid chromatography-UV, and the pharmacokinetic parameters were analyzed using a non-compartmental analysis. Following IV, IM, and SC administrations, the mean terminal half-life (t(1/2 lambda z)) was 11.48, 12.64, and 24.86 h, respectively, and the mean residence time (MRT) was 7.27, 7.81, and 10.11 h, respectively. The bioavailability (F) was 96.01 and 126.39%, after IM and SC administration, respectively. This study showed that SC administration of MB at a dose of 3 mg/kg exhibited flip-flop pharmacokinetics in lambs. These results suggested that MB could be useful in the treatment of severe systemic infections, such as those with M. haemolytica (MIC = 0.035 mu g/mL), in lambs since high AUC(0.24)/MIC and C-max/MIC ratios were achieved after IV and IM administration at 3 mg/kg. However, MB administration (3 mg/kg) via the IV, IM, and SC routes might not be effective in the treatment of respiratory infections caused by organisms with MIC90 value in lambs.en_US
dc.identifier.doi10.1016/j.smallrumres.2017.12.004en_US
dc.identifier.endpage10en_US
dc.identifier.issn0921-4488en_US
dc.identifier.issn1879-0941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.smallrumres.2017.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36837
dc.identifier.volume159en_US
dc.identifier.wosWOS:000425074600002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofSMALL RUMINANT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFluoroquinolonesen_US
dc.subjectMarbofloxacinen_US
dc.subjectPharmacokineticsen_US
dc.subjectLamben_US
dc.titlePharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneousen_US
dc.typeArticleen_US

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