Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database

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dc.contributor.authorYılmaz, Ü.
dc.contributor.authorAnlar, B.
dc.contributor.authorGücüyener, K.
dc.contributor.authorYaramış, A.
dc.contributor.authorCansu, A.
dc.contributor.authorÜnalp, A.
dc.contributor.authorAksoy, A.
dc.date.accessioned2020-03-26T19:43:43Z
dc.date.available2020-03-26T19:43:43Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey. Methods Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (?12 years) groups were compared. Results There were 123 (63.7%) girls and 70 (36.3%) boys aged 4–17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor symptoms (33.2%), and optic neuritis (26.4%) as common initial manifestations. Nineteen children had facial paralysis and 10 had epileptic seizures at first attack; 21 (11%) were initially diagnosed with acute disseminated encephalomyelitis (ADEM). Oligoclonal bands were identified in 68% of patients. Magnetic resonance imaging revealed periventricular (96%), cortical/juxtacortical (64.2%), brainstem (63%), cerebellum (51.4%), and spinal cord (67%) involvement. Visual evoked potentials (VEP) were abnormal in 52%; serum 25-hydroxyvitamin D levels were low in 68.5% of patients. The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease. Conclusion Brainstem and cerebellum are common sites of clinical and radiological involvement in pediatric-onset MS. VEP abnormalities are frequent even in patients without history of optic neuropathy. Vitamin D status does not appear to affect the course in early disease. MS beginning before 12 years of age has certain characteristics in history and course. © 2017 European Paediatric Neurology Societyen_US
dc.identifier.doi10.1016/j.ejpn.2017.06.004en_US
dc.identifier.endpage872en_US
dc.identifier.issn1090-3798en_US
dc.identifier.issue6en_US
dc.identifier.pmid28694135en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage864en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejpn.2017.06.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35742
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW.B. Saunders Ltden_US
dc.relation.ispartofEuropean Journal of Paediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectImagingen_US
dc.subjectMagnetic resonanceen_US
dc.subjectMultiple sclerosisen_US
dc.subjectPediatricen_US
dc.subjectRelapseen_US
dc.subjectVisual evoked potentialsen_US
dc.subjectVitamin Den_US
dc.titleCharacteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis databaseen_US
dc.typeArticleen_US

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