Investigation of novel monopodal and dipodal oxy-Schiff base triazine from cyanuric chloride: Structural and antimicrobial studies

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dc.contributor.authorKoc, Ziya Erdem
dc.contributor.authorUysal, Ahmet
dc.date.accessioned2020-03-26T19:24:50Z
dc.date.available2020-03-26T19:24:50Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDuring the last few years, the potential of s-triazine derivatives in agrochemical and medicinal properties have been subjected to investigation. s-Triazine derivatives have received great attention due to their significant antimicrobial, antibacterial, antifungal, anti-HIV, anticancer, and a wide array of other biological activities. The present study reported a method for achieving Dipodal systems formed by reaction 2,4,6-trichloro-1,3,5-triazine and 4-hydroxybenzaldehyde, 2-aminophenol. Herein, we reported the synthesis of a dialdehyde and its Schiff base as a new template. The reaction of cyanuric chloride with 1 equiv. methanol and 2 equiv. of p-hydroxybenzaldehyde gave the desired dialdehyde. The dialdehyde was then reacted with 2-aminophenolto afford the corresponding multidirectional oxy-Schiff base triazines. The structures of the compounds were identified by FT-IR,H-1-NMR and elemental analysis. Their antimicrobial activities were performed by using the broth microdilution method in DMSO: Phosphate Buffered Saline (PBS) against eight bacteria strain and one yeast strain. The results of the test were compared with gentamicin. It has been determined that 2,4-Bis(2-hydroxyphenylimino-4'-formylphenoxy)-6-methoxy-1,3,5-triazine (3) (2DP2AF) and 2-(2-hydroxyphenylimino-4'-formylphenoxy)-4-(4'-formylphenoxy)-6-methoxy-1,3,5-triazine (2) (1DP2AF) have significant antibacterial and antifungal activity against Enterococcus faecalis and Candida albicans and these effects were close to the control antibiotic used. Ent. faecalis was the most sensitive strain against both two tested chemicals. It was determined that our chemicals have similar antifungal capacity when compared to gentamicin.en_US
dc.identifier.doi10.1080/10601325.2016.1121060en_US
dc.identifier.endpage115en_US
dc.identifier.issn1060-1325en_US
dc.identifier.issn1520-5738en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10601325.2016.1121060
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33736
dc.identifier.volume53en_US
dc.identifier.wosWOS:000368553200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofJOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCyanuric chlorideen_US
dc.subjects-triazineen_US
dc.subjectSchiff basesen_US
dc.subjectantimicrobial activityen_US
dc.subjectbroth microdilutionen_US
dc.titleInvestigation of novel monopodal and dipodal oxy-Schiff base triazine from cyanuric chloride: Structural and antimicrobial studiesen_US
dc.typeArticleen_US

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