The Effect of Hypothyroidism on Color Contrast Sensitivity: A Prospective Study

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dc.contributor.authorCakir, Mehtap
dc.contributor.authorOzturk, Banu Turgut
dc.contributor.authorTuran, Elif
dc.contributor.authorGonulalan, Gulsum
dc.contributor.authorPolat, Ilker
dc.contributor.authorGunduz, Kemal
dc.date.accessioned2020-03-26T19:07:24Z
dc.date.available2020-03-26T19:07:24Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Thyroid hormone has been shown to control retinal cone opsin expression, the protein of color vision, in adult rodents. Objectives: The aim of this study was to evaluate the effect of hypothyroidism on color contrast sensitivity in adult overt hypothyroid patients. Methods: Thirtyeight overt hypothyroid (31 females, 7 males) subjects and 20 euthyroid (16 females, 4 males) controls were studied prospectively. Color vision examination was performed by Chromatest, a software program analyzing the tritan (blueyellow) color contrast threshold (tritan CCT) and protan (redgreen) color contrast threshold (protan CCT). Color contrast sensitivity analyses of hypothyroid subjects were performed on admission and after L -thyroxine treatment when biochemical euthyroidism was achieved. Results: After a median period of 90 (90-210) days, 24 (19 females, 5 males) patients were euthyroid and eligible for a second color vision examination. Baseline tritan CCT and protan CCT values were significantly higher in the hypothyroid group compared to euthyroid controls, which clinically translates into impaired color contrast sensitivity (p < 0.001 and p < 0.001, respectively). There was a significant decrease in tritan CCT (p = 0.002) and protan CCT (p < 0.001) values in the hypothyroid group after euthyroidism was achieved, which denotes improvement in color contrast sensitivity. Conclusions: It is a novel finding of the current study that color contrast sensitivity is impaired in hypothyroidism and significantly improves after euthyroidism is achieved. (C) 2015 European Thyroid Association Published by S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000371549en_US
dc.identifier.endpage47en_US
dc.identifier.issn2235-0640en_US
dc.identifier.issn2235-0802en_US
dc.identifier.issue1en_US
dc.identifier.pmid25960961en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000371549
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32628
dc.identifier.volume4en_US
dc.identifier.wosWOS:000218899400008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofEUROPEAN THYROID JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectThyroiden_US
dc.subjectHypothyroidismen_US
dc.subjectOpsinen_US
dc.subjectConeen_US
dc.subjectColor visionen_US
dc.titleThe Effect of Hypothyroidism on Color Contrast Sensitivity: A Prospective Studyen_US
dc.typeArticleen_US

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