Serum apolipoprotein B100 concentrations in dairy cows with left sided displaced abomasum

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dc.contributor.authorCivelek, T.
dc.contributor.authorSevinc, M.
dc.contributor.authorBoydak, M.
dc.contributor.authorBasoglu, A.
dc.date.accessioned2020-03-26T17:04:17Z
dc.date.available2020-03-26T17:04:17Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to examine the alteration in serum apolipoprotein B100 (apo B100) concentrations and to evaluate the liver steatosis in dairy cows with left sided displaced abomasum (LSDA). A total of 33 Holstein cows (9 clinically healthy and 24 with LSDA) were used. Serum concentrations of apo B100 were assayed by single radial immunodiffusion method. Serum total bilirubin, glucose, cholesterol, triglyceride, total protein, albumin and high density lipoprotein (HDL) concentrations and aspartate amino transferase (AST) and gamma glutamyl transferase (GGT) activities were measured colorimetric methods. Biopsy samples were obtained from liver under local anesthesia with percutaneous biopsy needle for histopathological examination. Serum apo B100 concentrations were significantly decreased in cows with LSDA (p < 0.001) and were associated to abnormal lipid biochemistry (marked decreases of triglyceride, cholesterol and lipoprotein concentrations, p < 0.001), and to cholestasis (significant inceases of total bilirubin concentrations (p < 0.001) and of serum GGT activities (p < 0.01)) leading to liver injury (marked increases of AST activities (p < 0.001), and decreases of total protein (p < 0.01) and albumin (p < 0.05) concentrations). Liver biopsies revealed a severe fat infiltration (41.5 +/- 2.5%) in cows with LSDA, and the degree of hepatic lipidosis was negatively correlated to apo B 100 concentrations (r = -0.591). These results suggest that the apo 13100 would be a marker for hepatic steatosis and would provide a non invasive alternative to liver biopsy for FL (fatty liver) diagnosis.en_US
dc.identifier.endpage365en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage361en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20669
dc.identifier.volume157en_US
dc.identifier.wosWOS:000240962900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONALE VETERINAIRE TOULOUSEen_US
dc.relation.ispartofREVUE DE MEDECINE VETERINAIREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfatty liveren_US
dc.subjectbiochemistryen_US
dc.subjectApo B100en_US
dc.subjectleft displacement of abomasumen_US
dc.subjectcowen_US
dc.titleSerum apolipoprotein B100 concentrations in dairy cows with left sided displaced abomasumen_US
dc.typeArticleen_US

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