Genetic analysis of MEFV gene pyrin domain in patients with Behcet's disease

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dc.contributor.authorDursun, Ahmet
dc.contributor.authorDurakbasi-Dursun, Hatice Gul
dc.contributor.authorZamani, Ayse Gul
dc.contributor.authorGulbahar, Zerrin Gulin
dc.contributor.authorDursun, Recep
dc.contributor.authorYakicier, Cengiz
dc.date.accessioned2020-03-26T17:03:37Z
dc.date.available2020-03-26T17:03:37Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives. Behcet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. Methods. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing. Results. Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient. Conclusion. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction between pyrin domains are needed to be further investigated. Copyright (c) 2006 Ahmet Dursun et al.en_US
dc.identifier.doi10.1155/MI/2006/41783en_US
dc.identifier.issn0962-9351en_US
dc.identifier.issn1466-1861en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/MI/2006/41783
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20510
dc.identifier.wosWOS:000240224100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofMEDIATORS OF INFLAMMATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleGenetic analysis of MEFV gene pyrin domain in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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