Association of sociodemographical features, antiviral treatment, and necroinflammatory activity with depression and anxiety in chronic hepatitis B patients

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dc.contributor.authorCelik, Mustafa
dc.contributor.authorDemir, Nazlim Aktug
dc.contributor.authorSumer, Sua
dc.contributor.authorDemir, Lutfi Saltuk
dc.date.accessioned2020-03-26T19:01:02Z
dc.date.available2020-03-26T19:01:02Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Psychiatric disorders like depression and anxiety are known to be more prevalent in patients with chronic hepatitis B than healthy individuals. This increased prevalence may be due to multiple factors such as psychological distress associated with having a chronic disease, necroinflammatory activity in liver, side effects of treatment with antiviral agents or interferons, and/or direct effect of hepatitis viruses on central nervous system. Purpose of this study was to evaluate several risk factors that may be associated with anxiety and depression in patients with chronic hepatitis B. Methods: This study included 195 chronic hepatitis B patients. A psychiatrist made clinical interviews with the patients and filled Sociodemographic Data Form, Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS). Needle biopsies were performed to 175 patients who met biopsy criteria of American Association for the Study of Liver Diseases. Knodell Histological Activity Index was used to evaluate biopsy materials. HBV DNA and ALT levels were measured from patients' sera. Findings: In the study sample, 119 patients were males and 76 were females. Mean HARS score was 7.3 +/- 6.2 and mean HDRS score was 8.8 +/- 6.6. Both HARS and HDRS scores were higher in females than males. HARS score was higher in patients with a family history of chronic hepatitis and both HARS and HDRS scores were higher in patients with comorbid medical illness. Alanine aminotransferase, HBV DNA levels, and level of fibrosis in liver biopsy didn't affect HARS or HDRS scores. Also, there wasn't a difference in HARS or HDRS scores according to patients' usage of pegylated interferon, or oral antiviral therapy. Conclusion: Multiple factors affect the relation between chronic hepatitis and psychiatric disorders like anxiety and depression. Results of our study suggest that female sex, presence of a family history for chronic hepatitis B, comorbidity of other medical diseases, and ethnic origin affect more than the level of necroinflammatory activity and cellular damage in the liver or antiviral treatments.en_US
dc.identifier.doi10.5455/apd.1414410600en_US
dc.identifier.endpage412en_US
dc.identifier.issn1302-6631en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://dx.doi.org/10.5455/apd.1414410600
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31877
dc.identifier.volume16en_US
dc.identifier.wosWOS:000358667900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherCUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALIen_US
dc.relation.ispartofANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectchronic hepatitis Ben_US
dc.subjectalpha interferonen_US
dc.subjectdepressionen_US
dc.subjectanxietyen_US
dc.titleAssociation of sociodemographical features, antiviral treatment, and necroinflammatory activity with depression and anxiety in chronic hepatitis B patientsen_US
dc.typeArticleen_US

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