The effects of chrysin in an experimental model of acute pancreatitis

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dc.contributor.authorAlptekin H.
dc.contributor.authorCalisir A.
dc.contributor.authorÖzturk B.
dc.contributor.authorUgurlu C.
dc.contributor.authorYormaz S.
dc.contributor.authorEce I.
dc.date.accessioned2020-03-26T20:20:57Z
dc.date.available2020-03-26T20:20:57Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPURPOSE: This experimental study was conducted to evaluate the possible effects of orally administered chrysin on acute pancreatitis. MATERIAL AND METHOD: Twenty four rats were procured. The animals were randomly divided into four groups. In Group I, only vehicle solution (5% dimethylsulfoksid) was administered, and in Group II, chrysin dissolved in the vehicle solution was administered for six days. In Group III and Group IV cerulein was administered to induce acute pancreatitis. In Group III, only vehicle solution was administered, and in Group IV, chrysin dissolved in the vehicle solution was administered orally for six days. Blood samples were analyzed and the pancreatic tissue specimens were evaluated for histopathological examination. RESULTS: Group III and Group IV, exhibited markedly higher levels of serum WBC, amylase, and lipase, compared with Groups I and II. In the pancreatitis induced groups, CRP and TOS values were found to be significantly higher. In Group II and Group IV, TAS values were significantly higher. The highest calculated OSI values were observed in Group III. Group IV OSI values were significantly lower than those in Group III and even in Group I. Noticeable histopathological changes were identified in the pancreatitis induced Groups III and IV. Compared with Group III, the extent and severity of pancreatic injuries were markedly lower in Group IV. CONCLUSION: Chrysin application reduced oxidative stress and histopathological parameters. The present study shows that chrysin can be used to treat pancreatic diseases. © 2020, Edizioni Luigi Pozzi. All rights reserved.en_US
dc.identifier.issn0003469Xen_US
dc.identifier.pmid32129177en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38707
dc.identifier.volume9en_US
dc.identifier.wosWOS:000596855100015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute pancreatitisen_US
dc.subjectCeruleinen_US
dc.subjectChrysinen_US
dc.titleThe effects of chrysin in an experimental model of acute pancreatitisen_US
dc.typeArticleen_US

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