Crepis foetida L. subsp rhoeadifolia (Bleb.) Celak. as a source of multifunctional agents: Cytotoxic and phytochemical evaluation

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorSarıkürkcü, Cengiz
dc.contributor.authorUyar, Pembegül
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorUysal, Şengül
dc.contributor.authorKoçak, Mehmet Sefa
dc.contributor.authorCeylan, Ramazan
dc.date.accessioned2020-03-26T19:01:37Z
dc.date.available2020-03-26T19:01:37Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe cytotoxic, anticholinesterase, antityrosinase and antioxidant effects of methanol extract from the flower of C. foetida subsp. rhoeadifolia (CFRME) were evaluated. The cytotoxic effect was investigated using HepG2, Caco-2, MCF-7 and MCF-10A cell lines. Enzyme inhibitory activities were tested by spectrophotometric methods. Different chemical assays were used to determine the antioxidant effects. In addition, phenolic constituents were quantified. High-performance liquid chromatographic (HPLC) analysis revealed that chlorogenic acid was the major phenolic component in the extract. The extract showed a strong antiproliferative, antioxidant, and anticholinesterase and antityrosinase effects. These findings suggest that C. foetida subsp. rhoeadifolia may be considered as a source of ingredients that can be used as food supplements. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jff.2015.06.041en_US
dc.identifier.endpage708en_US
dc.identifier.issn1756-4646en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage698en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jff.2015.06.041
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31972
dc.identifier.volume17en_US
dc.identifier.wosWOS:000360253300064en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF FUNCTIONAL FOODSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCrepis foetida subsp rhoeadifoliaen_US
dc.subjectAntiproliferativeen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntityrosinaseen_US
dc.subjectAntioxidant effectsen_US
dc.titleCrepis foetida L. subsp rhoeadifolia (Bleb.) Celak. as a source of multifunctional agents: Cytotoxic and phytochemical evaluationen_US
dc.typeArticleen_US

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