Diagnostic Value of Uric Acid to Differentiate Transudates and Exudates

Basit Öğe Kaydı
dc.contributor.authorUzun, Kürşat
dc.contributor.authorVural, Hüseyin
dc.contributor.authorÖzer, Faruk
dc.contributor.authorİmecik, Oktay
dc.date.accessioned2020-03-26T16:36:13Z
dc.date.available2020-03-26T16:36:13Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractUric acid is known to be an end product of purine metabolism. Increases in uric acid may be found in clinical conditions associated with tissue hypoxia. We have investigated the value of uric acid to differentiate between a transudate and exudate. In this study, we measured uric acid in the pleural fluid and the serum of 110 patients, 30 women and 80 men with a mean age of 49.5+/-19 years. Light's criteria were used to differentiate between a transudate and exudate. Mean serum uric acid was 496.7 +/- 153.4 mu mol/l in patients with transudates and 291.3 +/- 143.1 mu mol/l in patients with exudates. Mean pleural fluid uric acid was 487.7 +/- 165 mu mol/l in patients with transudates and 279.9 +/- 142.1 mu mol/l in patients with exudates. These data showed that the levels of serum and pleural uric acid were higher in transudates than exudates (p<0.01). However, there was no significant difference between pleural fluid/serum uric acid ratio of the two patient groups (p>0.05). The specificity and sensitivity of pleural uric acid for diagnosis of transudate effusions were 73% and 80.6%, respectively. The specificity and sensitivity of pleural uric acid for dia gnosis of transudate effusions from exudates without malignancy were 71.8% and 91.7%, respectively. The sensitivity and specificity of pleural lactate dehydrogenase for diagnosis of exudates were 82% and 89%; the sensitivity and specificity of pleural fluid/serum lactate dehydrogenase were 85% and 890/0; the sensitivity and specificity of pleural fluid/serum protein were 91% and 89%, respectively. Using all three of Light's criteria together, the sensitivity was 91% and its specificity was 94%. Our findings indicate that determination of uric acid in pleural fluid may be of diagnostic value in differential diagnosis of transudates and exudates. The sensitivity of pleural uric acid measurement was higher for exudates without malignancy. However, Light's criteria remain the best means of separating transudates from exudates.en_US
dc.identifier.citationUzun, K., Vural, H., Özer, F., İmecik, O., (2000). Diagnostic Value of Uric Acid to Differentiate Transudates and Exudates. Clinical Chemistry and Laboratory Medicine, 38(7), 661-665. Doi: 10.1515/CCLM.2000.095
dc.identifier.doi10.1515/CCLM.2000.095en_US
dc.identifier.endpage665en_US
dc.identifier.issn1434-6621en_US
dc.identifier.issue7en_US
dc.identifier.pmid11028772en_US
dc.identifier.startpage661en_US
dc.identifier.urihttps://dx.doi.org/10.1515/CCLM.2000.095
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17197
dc.identifier.volume38en_US
dc.identifier.wosWOS:000089840200012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzer, Faruk
dc.institutionauthorİmecik, Oktay
dc.language.isoenen_US
dc.publisherWalter De Gruyter & Coen_US
dc.relation.ispartofClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecturic aciden_US
dc.subjectpleural effusionen_US
dc.subjecttransudatesen_US
dc.subjectexudatesen_US
dc.titleDiagnostic Value of Uric Acid to Differentiate Transudates and Exudatesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7197.pdf
Boyut:
186.13 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Göğüs Hastalıkları/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu