Phenolic Composition, Antioxidant and Cytotoxic Prospective of three Linum species: A Potential Source of Novel Anticancer Pharmacophores

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorPicot, Carene M. N.
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMaskovic, Pavle Z.
dc.contributor.authorVujic, Jelena M.
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:55:03Z
dc.date.available2020-03-26T19:55:03Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe therapeutic potential of some Linum species has been reported previously. Nonetheless, several species of this genus warrant further scientific consideration. In this study, the phenolic composition, antioxidant activity (DPPH, phosphomolybdenum, iron chelating, hydroxyl radical and lipid peroxidation assays) and cytotoxicity effect (human rhabdomyosarcoma, human cervix carcinoma, and murine fibroblast cell lines) of ethyl acetate, methanol, and water extracts of three Linum species (Linum austriacum subsp. glaucescens, Linum hirsutum subsp. anatolicum, and Linum tenuifolium) were assessed. High performance liquid chromatography with diode-array detection (HPLC-DAD) analysis revealed the presence of ferulic acid, p-hydroxybenzoic acid, synapic acid, rutin, apigenin-glucoside, quercetin, luteolin, and naringenin in all the extracts. It was observed that the extracts (IC50 ranging from 42.07 to 51.66 mu g/mL) showed IC50 significantly (p<0.05) lower than ascorbic and gallic acid (> 1000 and 255.43 mu g/mL respectively) against lipid peroxidation. According to the American National Cancer Institute guidelines, the extracts showed low cytotoxicity (IC50 < 30 mu g/mL). However, the water extracts showed cytotoxicity effects (IC50 17.43 +/- 0.13 to 28.12 +/- 0.66 mu g/mL) against the studied cell lines as compared to the antineoplastic positive control (Cis-DDP). These findings support the use of these plants in the management of ROS mediated disorders and advocates for the need for further scientific evaluations to confirm the observed in vitro bioactivity. The cytotoxic potential coupled with the antioxidant property of the water extracts of these plant species is of particular interest which can open new avenues in the quest for novel anticancer drugs.en_US
dc.identifier.doi10.2174/1385272822666171227150938en_US
dc.identifier.endpage1696en_US
dc.identifier.issn1385-2728en_US
dc.identifier.issn1875-5348en_US
dc.identifier.issue17en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1690en_US
dc.identifier.urihttps://dx.doi.org/10.2174/1385272822666171227150938
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36845
dc.identifier.volume22en_US
dc.identifier.wosWOS:000447281500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.relation.ispartofCURRENT ORGANIC CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLinumen_US
dc.subjectantioxidanten_US
dc.subjectphenolicen_US
dc.subjectnutraceuticalsen_US
dc.subjectanticanceren_US
dc.subjectcytotoxicen_US
dc.subjectTurkeyen_US
dc.titlePhenolic Composition, Antioxidant and Cytotoxic Prospective of three Linum species: A Potential Source of Novel Anticancer Pharmacophoresen_US
dc.typeArticleen_US

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