DNA protection, antioxidant, antibacterial and enzyme inhibition activities of heartwood and sapwood extracts from juniper and olive woods

Basit Öğe Kaydı
dc.contributor.authorÖzkan, Osman Emre
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAkça, Mehmet
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorOlgun, Cağrı
dc.contributor.authorAltuner, Ergin Murat
dc.contributor.authorAteş, Saim
dc.date.accessioned2020-03-26T19:01:55Z
dc.date.available2020-03-26T19:01:55Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, DNA protective, antioxidant, antibacterial and enzyme inhibiting properties of methanol extracts obtained from juniper and olive heartwood and sapwood were determined. These extracts were tested by five antioxidant methods (DPPH scavenging, FRAP, CUPRAC, metal chelating and phosphomolybdenum). Generally, heartwood extracts of both species are more efficient for DPPH radical scavenging activity, cupric ion reducing activity, ferric reducing antioxidant power and metal chelating activity than sapwood extracts. When compared to heartwood extracts, sapwood extracts have larger inhibition zone in disk diffusion test. In addition, all extracts showed high antibacterial activity against Staphylococcus aureus. DNA protection of both extracts had a capacity to inhibit the DNA damage arisen from Fenton's reagent. The highest DNA protective activity was observed in juniper sapwood extract with 84%. Furthermore, other extracts also indicated more than 60% of DNA protective activity. Olive wood extracts displayed the strongest enzyme inhibition activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Although juniper heartwood extracts showed highest anti-amylase, anti-glucosidase and anti-tyrosinase effects, they had no ability for inhibition BChE. The methanol extracts of olive samples demonstrated the most antioxidant activity (DPPH, CUPRAC and FRAP). In addition, juniper samples showed the highest anti-amylase, anti-tyrosinase, metal chelating and DNA protective activity. According to these results, the extracts of juniper and olive wood can be considered as a source of natural bio active agents for dietary, pharmacological and medicinal applications. This research will also serve as a base for future studies about biological activities of wood extracts.en_US
dc.description.sponsorshipKastamonu University Scientific Projects Research OfficeKastamonu University [KUBAP-01/2013-37]en_US
dc.description.sponsorshipThis study was supported by the Kastamonu University Scientific Projects Research Office (Project Number KUBAP-01/2013-37).en_US
dc.identifier.doi10.1039/c5ra12302jen_US
dc.identifier.endpage72958en_US
dc.identifier.issn2046-2069en_US
dc.identifier.issue89en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage72950en_US
dc.identifier.urihttps://dx.doi.org/10.1039/c5ra12302j
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32016
dc.identifier.volume5en_US
dc.identifier.wosWOS:000360552000060en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherROYAL SOC CHEMISTRYen_US
dc.relation.ispartofRSC ADVANCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleDNA protection, antioxidant, antibacterial and enzyme inhibition activities of heartwood and sapwood extracts from juniper and olive woodsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu