Sezaryen operasyonlarında opioid eklenen ve eklenmeyen farklı dozlardaki levobupivakain etkinliğinin değerlendirilmesi
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Elektif sezaryen operasyonlarında, spinal anestezide intratekal morfin eklenen ve eklenmeyen farklı levobupivakain dozlarının, randomize, çift kör olarak karşılaştırılması amaçlandı.Gereç ve Yöntem: Bu çalışma, ASA I-II grubu 37-42 haftalık miadında sezaryen operasyonu için spinal anestezi uygulanan 60 gebe kadında prospektif, randomize, çift-kör olarak planlandı. Hastalar randomize edilerek iki gruba ayrıldı. Grup L’ye 12,5 mg (3 ml) levobupivakain, Grup LM’ye ise 10 mg levobupivakain 0.1 mg morfin (3 ml) intratekal uygulandı. Sensoryal ve motor blok süresi, postoperatif ilk 24 saatteki VAS ağrı skoru, ilk analjezi ihtiyacı süresi, hemodinamik ve solunumsal parametreler, sedasyon düzeyleri, Apgar skorları, hasta memnuniyeti ve komplikasyonlar kaydedildi.Bulgular: Gruplar arasında motor blok başlama ve sonlanma süresi, sensoryal bloğun başlama ve iki segment gerileme süresi ile hasta memnuniyeti açısından istatistiksel anlamlı fark yoktu. Grup L’de ilk analjezik ihtiyacı, Grup LM’ye göre daha erken ortaya çıktı (sırası ile; 158.6 31.8 dakika, 176.6 37.16 dakika). Sonuç: Levobupivakain dozunun azaltılmasına rağmen levobupivakaine düşük doz morfin eklenmesi ile, yan etki ve komplikasyon sıklığında belirgin artış olmadan benzer anestezi ve analjezi düzeylerine ulaşıldığı, ayrıca daha uzun süreli spinal analjezi sağlandığı sonucuna varıldı.
Purpose: The object of this randomized and double-blinded study was to compare the efficacy of intrathecally applied levobupivacaine at different doses with or without morphine added in elective Cesarean section operations with spinal anesthesia.Materials and Methods: The study was planned as prospective, randomized and double-blinded in ASA I-II group of sixty women who were 37-42 weeks pregnant and applied spinal anesthesia for cesarean section. Patients were randomized into two groups. 12.5 mg (3 ml) levobupivacaine to group L, 10 mg levobupivacaine 0.1 mg morphine (3 ml) to group LM were applied intrathecally. Sensory and motor block durations, postoperative immediate 24 hour VAS pain scores, time to the first need for analgesia, hemodynamic and respiratory parameters, sedation levels, APGAR scores, patients’ satisfaction and complications were recorded.Results: No significant difference was found between groups in terms of time to motor block formation and termination, time to sensory block formation and its two segment decline, and patients’ satisfaction. Rescue analgesic need for the first time in group L was earlier compare to group LM (158.6 31.8 minutes and 176.6 37.16 minutes respectively).Conclusion: Despite levobupivacaine dose reduction, its combination with low-dose morphine was resulted in prolongation of spinal analgesia without significant increase in the frequency of side effects and complications with similar anesthesia and analgesia levels.
Purpose: The object of this randomized and double-blinded study was to compare the efficacy of intrathecally applied levobupivacaine at different doses with or without morphine added in elective Cesarean section operations with spinal anesthesia.Materials and Methods: The study was planned as prospective, randomized and double-blinded in ASA I-II group of sixty women who were 37-42 weeks pregnant and applied spinal anesthesia for cesarean section. Patients were randomized into two groups. 12.5 mg (3 ml) levobupivacaine to group L, 10 mg levobupivacaine 0.1 mg morphine (3 ml) to group LM were applied intrathecally. Sensory and motor block durations, postoperative immediate 24 hour VAS pain scores, time to the first need for analgesia, hemodynamic and respiratory parameters, sedation levels, APGAR scores, patients’ satisfaction and complications were recorded.Results: No significant difference was found between groups in terms of time to motor block formation and termination, time to sensory block formation and its two segment decline, and patients’ satisfaction. Rescue analgesic need for the first time in group L was earlier compare to group LM (158.6 31.8 minutes and 176.6 37.16 minutes respectively).Conclusion: Despite levobupivacaine dose reduction, its combination with low-dose morphine was resulted in prolongation of spinal analgesia without significant increase in the frequency of side effects and complications with similar anesthesia and analgesia levels.
Açıklama
Anahtar Kelimeler
Acil Tıp, Adli Tıp, Alerji, Anatomi ve Morfoloji, Androloji, Anestezi, Biyofizik, Biyokimya ve Moleküler Biyoloji, Diş Hekimliği, Farmakoloji ve Eczacılık, Toksikoloji
Kaynak
Cukurova Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
0
Sayı
1
