Early effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depression

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dc.contributor.authorKaraküçük, Yalçın.
dc.contributor.authorBeyoglu, Abdullah.
dc.contributor.authorÇömez, Aysegül.
dc.contributor.authorOrhan, Fatma Özlem.
dc.contributor.authorDemir, Merve.
dc.date.accessioned2020-03-26T20:13:32Z
dc.date.available2020-03-26T20:13:32Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPURPOSE: To investigate the effects of SSRIs on cornea and lens density, intraocular pressure (IOP) and anterior chamber parameters, including anterior chamber volume (ACV), anterior chamber depth (ACD), corneal volume (CV) and central corneal thickness (CCT), in patients with depression during a three-month follow-up period. METHOD: In this prospective study, 31 total patients, who were prescribed SSRIs for depression, were recruited. Sertraline, 50?mg/daily, was given to ten patients; 11 received Escitalopram, 10?mg/daily; and ten were treated with Fluoxetine, 20?mg/daily. The parameters recorded were corneal density (CD), lens density (LD), IOP, ACV, ACD, CV and CCT at the start of treatment, as well as at one-week, one-month, and three-month follow-ups. RESULTS: The study revealed that there was no risk of cataract development from three months of SSRI intake. Significant decrease in ACD was recorded at the one-week follow up; however, after three months, this decrease was insignificant compared to the baseline. ACV, CV, CCT, CD and LD showed no significant alterations in any of the follow up examinations over the three-month period. IOP, however, significantly fell (a P value of 0.004). CONCLUSION: In this study, SSRI use does not seem to be associated with an increased risk of cataract or glaucoma or with changes in CD and LD. Long-term follow-up is necessary to determine the actual risk of cataract or glaucoma with SSRI intake.en_US
dc.identifier.citationKaraküçük, Y., Beyoglu, A., Çömez, A., Orhan, F. Ö., Demir, M. (2019). Early Effects of Selective Serotonin Reuptake Inhibitors (SSRIs) on Cornea and Lens Density in Patients with Depression. Psychiatry and Clinical Psychopharmacology, 29(4), 387-393.
dc.identifier.doi10.1080/24750573.2019.1673944en_US
dc.identifier.endpage393en_US
dc.identifier.issn2475-0573en_US
dc.identifier.issn2475-0581en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage387en_US
dc.identifier.urihttps://dx.doi.org/10.1080/24750573.2019.1673944
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37713
dc.identifier.volume29en_US
dc.identifier.wosWOS:000490027700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaraküçük, Yalçın.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofPSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnterior segmenten_US
dc.subjectcataracten_US
dc.subjectcorneal densityen_US
dc.subjectintraocular pressure (IOP)en_US
dc.subjectlens densityen_US
dc.subjectserotonin reuptake inhibitors (SSRIs)en_US
dc.titleEarly effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depressionen_US
dc.typeArticleen_US

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