Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rabbits

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dc.contributor.authorKaya, Halil
dc.contributor.authorKafali, Mehmet Ertugrul
dc.contributor.authorAydin, Kemal
dc.contributor.authorKocak, Sedat
dc.contributor.authorSahin, Mustafa
dc.contributor.authorDuran, Arif
dc.contributor.authorGul, Mehmet
dc.date.accessioned2020-03-26T18:41:45Z
dc.date.available2020-03-26T18:41:45Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Methods: Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups. Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope. Results: While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology. Conclusion: Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.en_US
dc.description.sponsorshipScientific Research Projects Committee of Selcuk University, Konya, TurkeySelcuk Universityen_US
dc.description.sponsorshipThe study was financially supported by the Scientific Research Projects Committee of Selcuk University, Konya, Turkey. We would like to thank the committee for their contributions.en_US
dc.identifier.endpage37en_US
dc.identifier.issn0030-9982en_US
dc.identifier.issue1en_US
dc.identifier.pmid23865129en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29457
dc.identifier.volume63en_US
dc.identifier.wosWOS:000312677900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPAKISTAN MEDICAL ASSOCen_US
dc.relation.ispartofJOURNAL OF THE PAKISTAN MEDICAL ASSOCIATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAprotininen_US
dc.subjectTraumaen_US
dc.subjectAcute lung injuryen_US
dc.subjectPulmonary contusionen_US
dc.titleEfficacy of aprotinin treatment on bilateral blunt chest trauma created in rabbitsen_US
dc.typeArticleen_US

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