Expression of epidermal growth factor (egf) and heparin-binding egf (hb-egf) mrna in mare endometrium

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dc.contributor.authorAtli M.O.
dc.contributor.authorGüzeloğlu A.
dc.contributor.authorKurar E.
dc.contributor.authorKayiş S.A.
dc.contributor.authorAslan S.
dc.contributor.authorSemacan A.
dc.contributor.authorÇelik S.
dc.date.accessioned2020-03-26T18:32:19Z
dc.date.available2020-03-26T18:32:19Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümüen_US
dc.description.abstractEGF and HB-EGF play crucial roles in embryonic development and peri-implantation. In this study, aim was to characterize expression profiles of EGF and HB-EGF in mare endometrium during estrous cycle and early pregnancy. Endometrium biopsies were obtained from mares on day of ovulation (d0), late diestrus (LD) and after luteolysis (AL) in the estrus phase. In pregnant groups, biopsies were taken on days 14 (P14), 18 (P18), 22 (P22) and 60 (P60). Relative expression levels of genes were quantified using real-time RT-PCR. A mixed model was fitted on the normalized data and Least Significant Difference (LSD) test was employed to determine significantly different group(s). EGF mRNA expression was up-regulated at LD compared to d0 while HB-EGF expression was not changed throughout the cycle. EGF expression was also increased during early pregnancy with the highest expression level observed on P60. Similarly, HB-EGF mRNA level was increased on P60. Pregnancy induced EGF expression on P14 and P18 compared to LD and AL whereas expression of HB-EGF was only significantly higher on P18 than that of AL. These results indicate that EGF expression is up-regulated during the cycle at late diestrus when P4 is high and is increased by pregnancy. HB-EGF expression is induced later in the pregnancy. In conclusion, EGF and HB-EGF appear to involve in the events that happen in the mare endometrium during peri-implantation period.en_US
dc.identifier.citationAtlı, M. O., Güzeloğlu, A., Kurar, E., Kayış, S. A., Aslan, S., Semacan, A., Çelik, S. (2012). Expression of Epidermal Growth Factor (EGF) and Heparin-Binding EGF (HB-EGF) mRNA in Mare Endometrium. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 18(3), 463-467.
dc.identifier.endpage467en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage463en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28666
dc.identifier.volume18en_US
dc.identifier.wosWOS:000302602000019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGüzeloğlu A.
dc.institutionauthorKurar E.
dc.institutionauthorKayiş S.A.
dc.institutionauthorSemacan A.
dc.language.isoenen_US
dc.publisherVeteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEGFen_US
dc.subjectEndometriumen_US
dc.subjectHB-EGFen_US
dc.subjectMareen_US
dc.subjectPregnancyen_US
dc.titleExpression of epidermal growth factor (egf) and heparin-binding egf (hb-egf) mrna in mare endometriumen_US
dc.title.alternativeKısrak endometriumunda epidermal growth factor (egf) ve heparin-binding egf (hb-egf) mrna ekspresyonuen_US
dc.typeArticleen_US

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