The effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veteriner Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada akut kadmiyum toksikasyonuna maruz kalan ratlarda quercetinin bazı kan parametreleri ile antioksidan sistem üzerine etkilerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Bu amaç doğrultusunda, canlı ağırlıkları birbirine yakın olarak seçilmiş 30 adet yetişkin erkek “WistarAlbino” rat kullanıldı. Çalışmada kullanılan hayvanlar Kontrol grubu (K), Kadmiyum grubu (Cd), Quercetin grubu (Q) ve Kadmiyum + Quercetin grubu (CdQ) olmak üzere dört gruba ayrıldı. Cd grubunda yer alan ratlara 3 gün boyunca 4mg/kg/ canlı ağırlık/gün dozunda kadmiyum klorür (CdCl2) subkutan olarak uygulanırken, Q ve CdQ grubundaki ratlara ise 50 mg/ kg/canlı ağırlık/gün dozunda quercetin intraperitonal olarak yine 3 gün boyunca enjekte edildi. Kontrol grubunda yer alan ratlara herhangi bir uygulama yapılmadı. Kan örnekleri çalışmanın başlangıcından sonraki 4. günde toplandı. Bulgular: Deneme sonunda serum ve plazma örneklerinden SOD, MDA, GSH, katalaz, ALT, AST, GGT, total protein ve albümin düzeyleri belirlendi. Serum MDA düzeyinin sadece Cd uygulanan grupta önemli oranda yüksek olduğu belirlendi (P<0.05). ALT, AST ve GGT enzim düzeylerinin Cd grubunda, K ve Q gruplarına oranla daha fazla arttığı (P< 0.05) tespit edildi. Öneri: Sonuç olarak akut kadmiyum toksikasyonundan negatif etkilenen antioksidan sistem ve bazı kan parametrelerinin quercetin kullanımına bağlı olarak yeniden düzeldiği belirlenmiştir.
Aim: The aim of this study was to determine the effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity. Materials and Methods: Adult male “Wistar-Albino” rats (n = 30) were used and divided into four groups as Control (C, n = 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium + Quercetin (Cd + Q, n = 8). Cadmium chloride (CdCl2, 4 mg/ kg daily, s.c) were administrated to Cd and Cd+Q groups, and Quercetin (Q, 50 mg/kg daily, i.p) were given to Q and Cd + Q groups for 3 days, respectively. Control group was not recieved any treatment. Blood samples were collected from all animals at fourth day after treatments. Results: The levels of serum SOD, MDA, GSH, catalase, and plasma ALT, AST, GGT, total protein, albumin were detected. Although, serum MDA levels were found higher (P< 0.05) in Cd than the other groups, it was similiar in Q and C groups. ALT, AST and GGT enzyme levels were observed higher in Cd than C and Q groups (P< 0.05). Conclusion: Negative effects of acute cadmium toxicity on antioxidan system and some hematological parameters were ameliorated with quercetin treatment in rats.
Aim: The aim of this study was to determine the effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity. Materials and Methods: Adult male “Wistar-Albino” rats (n = 30) were used and divided into four groups as Control (C, n = 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium + Quercetin (Cd + Q, n = 8). Cadmium chloride (CdCl2, 4 mg/ kg daily, s.c) were administrated to Cd and Cd+Q groups, and Quercetin (Q, 50 mg/kg daily, i.p) were given to Q and Cd + Q groups for 3 days, respectively. Control group was not recieved any treatment. Blood samples were collected from all animals at fourth day after treatments. Results: The levels of serum SOD, MDA, GSH, catalase, and plasma ALT, AST, GGT, total protein, albumin were detected. Although, serum MDA levels were found higher (P< 0.05) in Cd than the other groups, it was similiar in Q and C groups. ALT, AST and GGT enzyme levels were observed higher in Cd than C and Q groups (P< 0.05). Conclusion: Negative effects of acute cadmium toxicity on antioxidan system and some hematological parameters were ameliorated with quercetin treatment in rats.
Açıklama
Anahtar Kelimeler
Antioksidanlar, kan parametreleri, kadmiyum, quersetin, ratlar, Antioxidants, blood parameters, cadmium, quercetin, rats
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
35
Sayı
2
Künye
Kısadere, İ., Dönmez, N., (2019). The effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity. Eurasian Journal of Veterinary Sciences, 35 (2), 66-70. DOI: 10.15312/EurasianJVetSci.2019.225
