The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KURE ILETISIM GRUBU A S
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: In this study we aimed to evaluate the relationship between serum leptin. levels, metabolic syndrome and treatment in bipolar patients. Method: Sixty bipolar I disorder (BD) patients were enrolled; 29 patients were on mood stabilizer (MS) (lithium, valproic acid, carbamazepin, and lamotrigine) treatment, 31 patients were on atypical antipsychotics (AA) (risperidone, quetiapine, and olanzapine) for at least 3 months. Metabolic syndrome (MetS) was evaluated according to NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Programme) criteria. Results: 36.7% of the patients were recognized as MetS. The AA subgroup had significantly more MetS than MS. Abdominal obesity was significantly correlated with leptin levels in BD. No significant association was found between MetS and leptin levels in BD. Discussion: AA taking bipolar patients had higher MetS rates. However, there was no significant difference among AAs for inducing MetS. Leptin levels were significantly correlated with abdominal obesity in bipolar patients but seem not to be associated with MetS.
Açıklama
Anahtar Kelimeler
bipolar disorder, metabolic syndrome, leptin, atypical antipsychotics
Kaynak
KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
18
Sayı
2
