Synthesis of new chiral calix[4]arene diamide derivatives for liquid phase extraction of alpha-amino acid methylesters

The synthesis of chiral diamide derivatives of calix[4]arene from the reaction of p-tert-butylcalix[4]arene diester la and calix[4]arene diester 1b with various amino alcohols were reported. The H-1 and C-13 NMR, data showed that the compounds synthesized exist in the cone conformation. The extraction study properties of these new compounds 3a,b-4a,b towards some selected alpha-amino acid methylesters are also reported. (c) 2006 Elsevier Ltd. All rights reserved.