Gold-based Nano-adjuvants

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dc.contributor.authorYavuz, E.
dc.contributor.authorBagriacik, E. U.
dc.date.accessioned2020-03-26T19:41:49Z
dc.date.available2020-03-26T19:41:49Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description7th IEEE International Conference Nanomaterials - Application and Properties (NAP) -- SEP 10-15, 2017 -- Odessa, UKRAINEen_US
dc.description.abstractGold nanocages (AuNCs) were synthesized via galvanic replacement method and characterized by TEM and UV-Vis-NIR. In order to investigate the adjuvant potential of AuNCs, AuNC-formulated recombinant Hepatitis B surface antigen (HBsAg) preparations were used. First, the adsorption efficiency and cumulative release percentage of newly created HBsAg-AuNC formulations were characterized. Then, their adjuvant responses in RAW 264.7 macrophages were systematically analysed in vitro by real time cell analysis system, flow cytometry, confocal microscopy, and ELISA. We have observed that HBsAg-AuNC vaccine formulations were stable and have uptaken easily by macrophages but not into the nucleus, and triggered the immune maturation of RAW 264.7 cells. Here in vitro studies have shown that Au nanocages with superior properties may be considered as a new adjuvant candidate alternative to alum.en_US
dc.description.sponsorshipIEEE, Minist Educ Sci Ukraineen_US
dc.description.sponsorshipScientific and Technology Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [214S652]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technology Research Council of Turkey (TUBITAKGrant214S652)en_US
dc.identifier.isbn978-1-5386-2810-2
dc.identifier.issn2306-580Xen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35157
dc.identifier.wosWOS:000426973100144en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.relation.ispartofPROCEEDINGS OF THE 2017 IEEE 7TH INTERNATIONAL CONFERENCE NANOMATERIALS: APPLICATION & PROPERTIES (NAP)en_US
dc.relation.ispartofseriesProceedings of the international conference Nanomaterials-Applications and properties
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgold nanocagesen_US
dc.subjectadjuvanten_US
dc.subjectmacrophagesen_US
dc.subjectHepatitis B vaccineen_US
dc.titleGold-based Nano-adjuvantsen_US
dc.typeConference Objecten_US

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