Histological and histomorphometric studies on the cerebellar cortex and silver stained nucleolus organizer regions of Purkinje neurons in chronic morphine-treated rats

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dc.contributor.authorCelik, Ilhami
dc.contributor.authorSeker, Muzaffer
dc.contributor.authorSalbacak, Ahmet
dc.date.accessioned2020-03-26T19:54:10Z
dc.date.available2020-03-26T19:54:10Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of chronic morphine administration on the rat cerebellum and silver stained nucleolus organizer regions in Purkinje cells were investigated by means of histological, histochemical and histometrical techniques. Thirty-two young (30-32 days of age) Wistar rats (equal numbers of both genders) were randomly divided into 2 groups, as control and morphine-treated, each having equal numbers of both genders, a total of 16 animals. The control animals were injected subcutaneously with 1mL/kg physiological saline, and the morphine-treated rats received 5 mg/kg morphine hydrochloride subcutaneously at daily intervals for 30 days. The thickness of the molecular and granular layers of the cerebellum, the diameters of the nuclei and nucleoli of cerebellar Purkinje neurones, and the number and size of the silver staining nucleolus organizer regions of the Purkinje cell nuclei were determined histomorphometrically. The morphine administration caused slight histological changes in the cerebellum. The molecular layer thickness of the cerebellum was significantly (P<0.05) reduced, and the decrease was mainly in the male animals. In contrast, the layer thickened insignificantly in the morphine-treated females. The granular layer thickened slightly but insignificantly in both genders of the morphinetreated group. The Purkinje cell count significantly decreased with morphine treatment. Nucleus size did not change with morphine treatment. However, morphine-treated animals had smaller nucleoli. It was concluded that morphine treatment caused significant histomorphological changes in the cerebellar cortex in a sexually dimorphic manner.en_US
dc.identifier.doi10.24099/vet.arhiv.160902aen_US
dc.identifier.endpage88en_US
dc.identifier.issn0372-5480en_US
dc.identifier.issn1331-8055en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://dx.doi.org/10.24099/vet.arhiv.160902a
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36675
dc.identifier.volume88en_US
dc.identifier.wosWOS:000425136100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUNIV ZAGREB VET FACULTYen_US
dc.relation.ispartofVETERINARSKI ARHIVen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmorphineen_US
dc.subjectrat cerebellumen_US
dc.subjectPurkinje neuroneen_US
dc.titleHistological and histomorphometric studies on the cerebellar cortex and silver stained nucleolus organizer regions of Purkinje neurons in chronic morphine-treated ratsen_US
dc.typeArticleen_US

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