A Comparative Study of the Effect of Rofecoxib (a COX 2 Inhibitor) and Naproxen Sodium on Analgesic Requirements After Abdominal Hysterectomy

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dc.contributor.authorÇelik, Jale Bengi
dc.contributor.authorTuncer, Sema
dc.contributor.authorReisli, Ruhiye
dc.contributor.authorSarkılar, Gamze
dc.contributor.authorÇelik, Çetin
dc.contributor.authorAkyürek, Cemalettin
dc.date.accessioned2020-03-26T16:46:30Z
dc.date.available2020-03-26T16:46:30Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study evaluated the analgesic efficacy of administering preoperatively rofecoxib or naproxen sodium to patients undergoing abdominal hysterectomy. A randomized, double-blinded prospective study was conducted with 60 women undergoing elective abdominal hysterectomy under general anesthesia. Patients were randomly allocated into one of three equally sized groups. Patients in the first group received rofecoxib 50 mg 1 h before operation (group R), patient in the second group received naproxen sodium 550 mg 1 h before surgery (group N) and patients in the third group received a placebo tablet in the same time (group P). Total amount of used morphine mixture was higher in placebo group (93±6 ml) than in the group R (50±4 ml) and group N (64±6 ml). There were significant difference for total amount of used morphine mixture between group P and other two groups. There was significant difference in the volumes of morphine mixture used in the first 12 h in group P and other two groups. The occurrence of side effects such as, dyspepsia, epigastric discomfort, heartburn, were similar in group R and group P. However, this side effects were increased in group N. Rofecoxib receiving preoperatively was provided clinical efficacy for postoperative pain control and well tolerated for gastrointestinal side effects comparable with naproxen sodium.en_US
dc.identifier.citationÇelik, J. B., Tuncer, S., Reisli, R., Sarkılar, G., Çelik, Ç., Akyürek, C., (2003). A Comparative Study of the Effect of Rofecoxib (a COX 2 Inhibitor) and Naproxen Sodium on Analgesic Requirements After Abdominal Hysterectomy. Archives of Gynecology and Obstetrics, 268(4). 297-300. Doi: 10.1007/s00404-002-0377-5
dc.identifier.doi10.1007/s00404-002-0377-5en_US
dc.identifier.endpage300en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issue4en_US
dc.identifier.pmid14504873en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-002-0377-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18666
dc.identifier.volume268en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇelik, Jale Bengi
dc.institutionauthorTuncer, Sema
dc.institutionauthorReisli, Ruhiye
dc.institutionauthorSarkılar, Gamze
dc.institutionauthorÇelik, Çetin
dc.institutionauthorAkyürek, Cemalettin
dc.language.isoenen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNaproxenen_US
dc.subjectPostoperative Analgesiaen_US
dc.subjectRofecoxiben_US
dc.titleA Comparative Study of the Effect of Rofecoxib (a COX 2 Inhibitor) and Naproxen Sodium on Analgesic Requirements After Abdominal Hysterectomy en_US
dc.typeArticleen_US

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