Mean platelet volume could be a possible biomarker for papillary thyroid carcinomas

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dc.contributor.authorBaldane S.
dc.contributor.authorIpekci S.H.
dc.contributor.authorSozen M.
dc.contributor.authorKebapcilar L.
dc.date.accessioned2020-03-26T19:08:24Z
dc.date.available2020-03-26T19:08:24Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThyroid cancer is the most prevalent endocrine cancer and is evident in nearly 5% of thyroid nodules. The correlation between mean platelet volume (MPV) and many other cancer types has been investigated previously. However, the correlation between papillary thyroid carcinoma (PTC) and MPV has not yet been studied in detail. The aim of this study was to examine whether MPV would be a useful inflammatory marker to differentiate PTC patients from cases of benign goiter and healthy controls. Preoperative MPV levels in patients with PTC were found to be significantly higher when compared with benign goiter patients and healthy controls ((respectively, 8.05 femtoliter (fl), 7.57 fl, 7.36 fl, p=0.001). After surgical treatment of PTC patients, a significant decrease in MPV levels was seen (8.05 fl versus 7.60 fl, p=0.005). ROC analysis suggested 7.81 as the cut-off value for MPV (AUC=0.729, sensitivity 60%, specificity 80%). In conclusion, maybe changes in MPV levels can be used as an easily available biomarker for monitoring the risk of PTC in patients with thyroid nodules, enabling early diagnosis of PTC.en_US
dc.identifier.doi10.7314/APJCP.2015.16.7.2671en_US
dc.identifier.endpage2674en_US
dc.identifier.issn1513-7368en_US
dc.identifier.issue7en_US
dc.identifier.pmid25854344en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2671en_US
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2015.16.7.2671
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32838
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization for Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMean platelet volume could be a possible biomarker for papillary thyroid carcinomasen_US
dc.typeArticleen_US

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