Effect of the FSH receptor polymorphism on the age at menarche

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dc.contributor.authorKerimoglu, O. S.
dc.contributor.authorPekin, A.
dc.contributor.authorYilmaz, S. A.
dc.contributor.authorIncesu, F. N.
dc.contributor.authorNergiz, S.
dc.contributor.authorDogan, N. U.
dc.contributor.authorAcar, H.
dc.date.accessioned2020-03-26T20:13:43Z
dc.date.available2020-03-26T20:13:43Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEstrogen and estrogen receptor (ER) genes have an effect on the age at menarche. Follicle stimulating hormone (BID is an important hormone that plays a major role in the regulation of folliculogenesis and estrogen synthesis. The aim of this study was to investigate the influence of the FSH receptor (FSHR) polymorphisms Asn680Ser and Thr307Ala on age at menarche. Materials and Methods: FSH receptor gene polymorphisms were investigated in women who were admitted to Selcuk University between May 2013 and November 2014. Information about age at menarche was obtained through interviews. Polymorphic analysis of the FSH receptor gene was performed in 209 healthy female patients who had undergone an annual health examination. Genomic DNA was obtained from peripheral blood leukocytes, and polymorphisms were investigated using restriction fragment length polymorphism analysis. Results: The mean age at menarche was 12.95 +/- 1.62 years. The overall frequencies for Asn680Ser variants NN, NS, and SS were 40.2%, 36.4%, and 23.4%, respectively, whereas Thr307Ala variants TT, TA, and AA were 34.4%, 41.1%, and 24.4%, respectively. Menarche occurred 3.6 months earlier in subjects with TN homozygote genotype than in AS homozygotes, and the mean age at menarche was 2.5 months earlier in TN homozygotes compared with that in all other study subjects, but the differences were not statistically significant (p = 0.966 and p = 0.986, respectively). Conclusions: The Ala307Thr and Ser680Asn polymorphisms of the FSHR gene are not associated with age at menarche.en_US
dc.description.sponsorshipSelcuk University Scientific Project Funden_US
dc.description.sponsorshipThis study is funded by Selcuk University Scientific Project Fund.en_US
dc.identifier.doi10.12891/ceog4401.2019en_US
dc.identifier.endpage244en_US
dc.identifier.issn0390-6663en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://dx.doi.org/10.12891/ceog4401.2019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37748
dc.identifier.volume46en_US
dc.identifier.wosWOS:000474747400013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisher7847050 CANADA INCen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMenarche ageen_US
dc.subjectFSH receptoren_US
dc.subjectPolymorphismen_US
dc.subjectEstrogen receptoren_US
dc.titleEffect of the FSH receptor polymorphism on the age at menarcheen_US
dc.typeArticleen_US

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