Evaluation of the therapeutic effects of Artemisia absinthium L. on pseudopregnancy model in rats

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dc.contributor.authorDemirel, Mürşide Ayşe
dc.contributor.authorSuntar, İpek
dc.contributor.authorÇeribaşı, Songül
dc.contributor.authorZengin, Gökhan
dc.contributor.authorÇeribaşı, Ali Osman
dc.date.accessioned2020-03-26T19:53:53Z
dc.date.available2020-03-26T19:53:53Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractResearchers have been investigating new treatment strategies for the management of pseudopregnancy, due to some long term causes of this disease including mastitis and mammary tumor. Owing to the side effects of hormone therapy, much attention has been focused on more tolerable treatment options including natural remedies. In the present study, we aimed to investigate the therapeutic effects of Artemisia absinthium L. (wormwood) on pseudopregnancy model in rats. A. absinthium, which is a perennial shrubby plant from Asteraceae family, was reported to be used as an emmenagogue in folk medicine and was previously shown to modulate dopaminergic system. In the present study, pseudopregnancy model was induced in female Sprague-Dawley rats by injection of pregnant mare's serum gonadotropin and human chorionic gonadotropin. The petroleum ether, dichloromethane and methanol extracts of A. absinthium, prepared by successive extraction method, were orally administered to the rats at 100 mg/kg dose, once daily for 10 days. Bromocriptine (3 mg/kg/per os) was administered to the reference group animals. At the end of the experiment, all of the animals were sacrificed, the blood samples, ovaries and uterine tissues were taken for histopathological and biochemical analysis. According to the results of the present study, the petroleum ether extract displayed beneficial effects in pseudopregnancy model in rats when compared with the control group. Therefore, Gas Chromatography analysis was conducted on this extract to reveal its phytochemical profile.en_US
dc.identifier.doi10.1007/s11101-018-9571-3en_US
dc.identifier.endpage946en_US
dc.identifier.issn1568-7767en_US
dc.identifier.issn1572-980Xen_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage937en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11101-018-9571-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36612
dc.identifier.volume17en_US
dc.identifier.wosWOS:000442001300017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPHYTOCHEMISTRY REVIEWSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsteraceaeen_US
dc.subjectArtemisia absinthiumen_US
dc.subjectDopaminergicen_US
dc.subjectPseudopregnancyen_US
dc.subjectRaten_US
dc.titleEvaluation of the therapeutic effects of Artemisia absinthium L. on pseudopregnancy model in ratsen_US
dc.typeArticleen_US

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