Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

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dc.contributor.authorBakırhan, Nurgül Karadaş
dc.contributor.authorAkmeşe, Bediha
dc.contributor.authorGöver, Tuğce
dc.contributor.authorImanzadeh, Hamideh
dc.contributor.authorÖzkan, Sibel A.
dc.date.accessioned2020-03-26T20:13:14Z
dc.date.available2020-03-26T20:13:14Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe degradation of daunorubicin (DNR), doxorubicin (DXR) and vincristine (VCR) as chemotherapeutic agents was investigated under stress conditions such as acidic and alkaline media, oxidation, photolytic and heating. The degradation pathway determined by high-performance liquid chromatography (HPLC). Daunorubicin, doxorubicin and vincristine completely disintegrated in the basic medium. It has been determined that these drugs are resistant to heat. Daunorubicin and doxorubicin are resistant to UV light. However, vincristine is not very stable such as the other two compounds against UV light. The kinetic and thermodynamic parameters of daunorubicin, doxorubicin and vincristine were investigated in neutral media with different temperatures by electrochemical technique. Enthalpy, entropy and Gibbs free energy parameters were investigated in pH 7.4 phosphate buffer (PB) solution due to stability of these drugs at this pH. The studied chemotherapeutic agents showed endothermic process on glassy carbon-based electrode surface. Daunorubicin, doxorubicin and vincristine showed strongly adsorption process in room temperature. However, it showed diffusion property from electrode to solution with increasing the temperature values.en_US
dc.identifier.citationBakırhan, N. K., Akmeşe, B., Göver, T., Imanzadeh, H., Özkan, S. A. (2019). Degradation Studies and Thermodynamic Parameters in Aqueous Solution of Chemotherapeutic Agents: Daunorubicin, Doxorubicin and Vincristine. Journal of Research in Pharmacy, 23(5), 822-831.
dc.identifier.doi10.35333/jrp.2019.30en_US
dc.identifier.endpage831en_US
dc.identifier.issn2630-6344en_US
dc.identifier.issue5en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage822en_US
dc.identifier.urihttps://dx.doi.org/10.35333/jrp.2019.30
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37650
dc.identifier.volume23en_US
dc.identifier.wosWOS:000485773700007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGöver, Tuğce.
dc.language.isoenen_US
dc.publisherMARMARA UNIVen_US
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDegradationen_US
dc.subjectliquid chromatographyen_US
dc.subjectdrug stabilityen_US
dc.subjectchemotherapeutic agenten_US
dc.subjecttemperature effecten_US
dc.titleDegradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristineen_US
dc.typeArticleen_US

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