Metabolomic profile of Salvia viridis L. root extracts using HPLC-MS/MS technique and their pharmacological properties: A comparative study

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Fawzi
dc.contributor.authorPicot-Allain, Carene
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorCvetanovic, Aleksandra
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorZeković, Zoran
dc.contributor.authorRengasamy, Kannan R.R.
dc.date.accessioned2020-03-26T20:15:11Z
dc.date.available2020-03-26T20:15:11Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractSeveral Salvia species have received due scientific attention regarding their therapeutic virtues, yet little is known about the pharmacological potential of Salvia viridis L. roots. This study, therefore, attempts to explore the phytochemical composition, enzyme inhibitory potential, and antioxidant activities of S. viridis ethanolic root extracts obtained by different extraction methods, namely microwave-assisted extraction, maceration, supercritical fluid extraction, Soxhlet extraction, and ultrasonic assisted extraction. The extract produced by ultrasonic assisted extraction possessed the highest phenolic and flavonoid contents (111.41 mg gallic acid equivalent/g extract and 23.46 mg rutin equivalent/g extract). S. viridis ethanolic root extract obtained by ultrasonic assisted extraction showed highest radical scavenging (240.00 and 302.85 mg Trolox equivalent TE/g for DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid) assays, respectively) and reducing (970.74, 704.27 mg TE/g, and 2.84 mmol TE/g for CUPRAC (cupric reducing antioxidant capacity), FRAP (ferric reducing antioxidant power), and phosphomolybdenum assays, respectively) activities. Chemical profiles of these extracts were investigated by HPLC MS/MS, and the profiles (23 components) of the supercritical fluid extract was different from other extraction techniques. The study reports for the first time, the inhibitory action of ethanolic root extract of S. viridis on key enzymes related to Alzheimer's disease (acetylcholinesterase, butyrylcholinesterase), diabetes (a-amylase, a-glucosidase), and skin hyperpigmentation disorders (tyrosinase). Data generated from this study appraises the multiple biological activities of plants belonging to the Salvia genus. Scientific evidence gathered in this study support further investigations which might lead to the development of new pharmaceutical entities for the management of diabetes, Alzheimer's disease, and skin hyperpigmentation conditions.en_US
dc.identifier.citationZengin, G., Mahomoodally, F., Picot-Allain, C., Diuzheva, A., Jekő, J., Cziáky, Z., Cvetanovic, A., Aktumsek, A., Zekovic, Z., Rengasamy, K. R. (2019). Metabolomic Profile of Salvia viridis L. Root Extracts Using HPLC–MS/MS Technique and Their Pharmacological Properties: A Comparative Study. Industrial Crops and Products, 131, 266-280.
dc.identifier.doi10.1016/j.indcrop.2019.01.060en_US
dc.identifier.endpage280en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.01.060
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37995
dc.identifier.volume131en_US
dc.identifier.wosWOS:000460991700032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSalvia viridisen_US
dc.subjectDiabetesen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectHyperpigmentationen_US
dc.subjectExtractionen_US
dc.subjectPhyto-pharmaceuticalsen_US
dc.titleMetabolomic profile of Salvia viridis L. root extracts using HPLC-MS/MS technique and their pharmacological properties: A comparative studyen_US
dc.typeArticleen_US

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