Cardiac safety of gamithromycin in ewes
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Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bir makrolid antibiyotik olan gamitromisin sığırlarda pasteurellosis tedavisinde önerilmekle birlikte koyunlarda etiket dışı olarak kullanılmaktadır. Makrolid antibiyotiklerin kardiyotoksik etkileri bilinmektedir, ancak gamitromisinin koyunlarda kardiyak güvenilirliği ile ilgili bilgi bulunmamaktadır. Araştırmanın öncelikli amacı koyunlarda gamitromisinin kardiyak güvenilirliğini belirlemektir. Bunun yanı sıra karaciğer ve böbrek fonksiyonlarına ve hemogram parametrelerine etkisini tespit etmektir.Gereç ve Yöntem: Araştırmada 10 adet koyuna gamitromisin (6 mg/kg, SC) tek doz olarak uygulandı. Kan örnekleri uygulamadan önce (0. gün, kontrol) ve sonraki 0.25, 0.5, 1, 2, 3, 4, 5, 6, 7, 8 ve 9. günlerde alındı. Spesifik kalp hasar belirteçleri olan serum kreatin kinaz-MB kütle ve troponin I düzeyleri, karaciğer ile böbrek hasar belirteçleri ve hemogram parametreleri ölçüldü. Bulgular: Araştırmada troponin I düzeyinde birinci gün istatistiki olmayan yükselmeler belirlenirken, kreatin kinaz-MB kütle düzeyinde değişimler belirlenmedi. Total bilirubin, total protein, kreatinin ve akyuvar düzeyinde referans değerler arasında istatistiki değişimler belirlendi (P0.05).
Aim: Gamithromycin, a macrolide antibiotic, is used in the treatment of bovine pasteurellosis, whereas it is used in sheep as extra-label. It is well known that macrolide antibiotics have cardiotoxic effect, however, it cannot be found the information of cardiac safety of gamithromycin in sheep in the literature. The first aim of this research was to determine the cardiac safety of gamithromycin in sheep. In addition, effects of gamithromycin on the liver and kidney functions and hemogram values were investigated. Materials and Methods: Gamithromycin (6 mg/kg, SC) was administered as a single dose to 10 sheep. Blood samples were taken before (0. day, control) and after treatments at 0.25, 0.5, 1, 2, 3, 4, 5, 6, 7, 8 and 9 days. Serum creatine kinease-MB mass and troponin I levels which are specific cardiac damage markers, liver, kidney damage markers and hemogram values were measured. Results: Increased troponin I levels were determined at first day but it was not statistically significant, and there was no change determined in the creatine kinase-MB mass levels. Statistically significant (P<0.05) fluctuations were determined in the total bilirubin, total protein, creatinine and white blood cell counts, but these results were within the normal ranges. Conclusion: It may be stated that single dose (6 mg/kg, SC) gamithromycin administration has no distinctive side effects on the heart, liver and kidney functions and hemogram values in sheep.
Aim: Gamithromycin, a macrolide antibiotic, is used in the treatment of bovine pasteurellosis, whereas it is used in sheep as extra-label. It is well known that macrolide antibiotics have cardiotoxic effect, however, it cannot be found the information of cardiac safety of gamithromycin in sheep in the literature. The first aim of this research was to determine the cardiac safety of gamithromycin in sheep. In addition, effects of gamithromycin on the liver and kidney functions and hemogram values were investigated. Materials and Methods: Gamithromycin (6 mg/kg, SC) was administered as a single dose to 10 sheep. Blood samples were taken before (0. day, control) and after treatments at 0.25, 0.5, 1, 2, 3, 4, 5, 6, 7, 8 and 9 days. Serum creatine kinease-MB mass and troponin I levels which are specific cardiac damage markers, liver, kidney damage markers and hemogram values were measured. Results: Increased troponin I levels were determined at first day but it was not statistically significant, and there was no change determined in the creatine kinase-MB mass levels. Statistically significant (P<0.05) fluctuations were determined in the total bilirubin, total protein, creatinine and white blood cell counts, but these results were within the normal ranges. Conclusion: It may be stated that single dose (6 mg/kg, SC) gamithromycin administration has no distinctive side effects on the heart, liver and kidney functions and hemogram values in sheep.
Açıklama
Anahtar Kelimeler
Veterinerlik
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
32
Sayı
4
Künye
Corum, O., Dik, B., Bahcivan, E., Eser, H., Er, A., Yazar, E. (2016). Cardiac Safety of Gamithromycin in Ewes. Eurasian Journal of Veterinary Sciences, 32(4), 242-245.
