Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

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dc.contributor.authorYildiz, R.
dc.contributor.authorOk, M.
dc.date.accessioned2020-03-26T19:34:21Z
dc.date.available2020-03-26T19:34:21Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSurfactant deficiency, poor development of the lung structure and fibrosis as a result of inflammation are thought to play an important role in the development of respiratory distress syndrome in premature calves. Nebulised steroid (fluticasone), bronchodilator (salbutamol) and diuretics (furosemide) can be used in combination alongside standard treatment procedures for premature calves, and might improve viability as observed in infants, foals and horses with pulmonary disorders. Twenty-five premature calves with respiratory distress syndrome were used in this study. Oxygen and supportive treatment were administered to all groups. The first group was used as a control group (Group 1). The nebulised drug combinations were as follows: Group 2: fluticasone + salbutamol, Group 3: salbutamol + furosemide, Group 4: fluticasone + furosemide and Group 5: fluticasone + salbutamol + furosemide. During the 72-h time period of the study, fluticasone (15 mu g/kg/12 h), salbutamol (0.025 mg/kg/6 h) and furosemide (1 mg/kg/12 h) were applied for 5 min. Arterial blood samples were collected from the auricular artery at 0 h and at 1, 24, 48 and 72 h for blood gas analysis. Significant (P < 0.05) increases in arterial partial oxygen, oxygen saturation and peripheral oxygen saturation and decreases in arterial partial carbon dioxide, lactate and respiration rate were observed in all the nebulised treatment groups, while a statistical difference was observed only for arterial partial carbon dioxide in control group. When comparing the treated groups with the control, it may be concluded that nebulised drugs are highly effective in the therapy of premature calves with respiratory distress syndrome, while the different nebulised groups exhibited similar efficacies.en_US
dc.description.sponsorshipSelcuk University Scientific Research Office [13102027]en_US
dc.description.sponsorshipSupported by the Selcuk University Scientific Research Office (Doctoral thesis project No. 13102027).en_US
dc.identifier.doi10.17221/34/2017-VETMEDen_US
dc.identifier.endpage552en_US
dc.identifier.issn0375-8427en_US
dc.identifier.issn1805-9392en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage541en_US
dc.identifier.urihttps://dx.doi.org/10.17221/34/2017-VETMED
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34882
dc.identifier.volume62en_US
dc.identifier.wosWOS:000414626800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCZECH ACADEMY AGRICULTURAL SCIENCESen_US
dc.relation.ispartofVETERINARNI MEDICINAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcalfen_US
dc.subjectarterial blood gasen_US
dc.subjectnebulised drugsen_US
dc.subjecttreatmenten_US
dc.titleClinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndromeen_US
dc.typeArticleen_US

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