Efficacies of Free and Liposome-Encapsulated Enrofloxacin (Baytril®) Against Staphylococcus Aureus Infection in Turkish Shepherd Dog Neutrophils in Vitro
Yükleniyor...
Dosyalar
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The influence of free and liposome-encapsulated enrofloxacin at concentrations of 1, 2 and 4 ?g/ml was studied on phagocytic and intracellular killing of Staphylococcus aureus, in cultured neutrophils of six healthy Turkish Shepherd Dogs. Enrofloxacin was encapsulated by using reverse-phase evaporation method in multilamellar liposomes composed of 15 mg egg phosphatidylcholine and 35 mg cholesterol. Phagocytic and killing activity of neutrophils were determined by fluorescent microscopic technique. Liposome-encapsulated enrofloxacin significantly enhanced the intraphagocytic killing of bacteria in neutrophils compared to free drug. Phagocytic activity of neutrophils was not significantly different among groups. The results obtained in the present study show that use of enrofloxacin encapsulated in liposomes may improve the antibacterial efficacy of the antibiotic.
Açıklama
Anahtar Kelimeler
Enrofloxacin, Intracellular bioactivity, Liposome, Neutrophil, Staphy-lococcus aureus, Turkish Shepherd Dog
Kaynak
Revue de Medecine Veterinaire
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
151
Sayı
5
Künye
Baş, A. L., Elmas, M., Şimşek, A., Traş, B., Yazar, E., Hadimli, H. H., (2000). Efficacies of Free and Liposome-Encapsulated Enrofloxacin (Baytril®) Against Staphylococcus Aureus Infection in Turkish Shepherd Dog Neutrophils in Vitro. Revue de Medecine Veterinaire, 151(5), 415-420.
